CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044286
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein 
Protein Synonyms/Alias
  
Gene Name
 Prex1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
971GIKKVCFKVSEDEQEphosphoglycerylation[1]
Reference
 [1] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1480 AA 
Protein Sequence
MLLGGRKTTD IPLEGYLLSP IQRICKYPLL LKELAKRTPG KHPDHTAVQS ALQAMKTVCS 60
NINETKRQME KLEALEQLQS HIEGWEGSNL TDICTELLLQ GNLLKISAGN IQERAFFLFD 120
NLLVYCKRKS RVTGSKKSTK RTKSINGSLY IFRGRINTEV MEVENVEDGT ADYHSNGYTV 180
TNGWKIHNTA KNKWFVCMAK TAEEKQKWLD ALIREREQRE SLKLGMERDA YVMIAEKGEK 240
LYHMMMSKKV NLIKDRRRKL STVPKCFLGN EFVAWLLEIG EISKTEEGVN LGQALLENGI 300
IHHVSDKHQF KNEQVMYRFR YDDGTYKARS ELEDIMSKGV RLYCRLHSLY APVIKDRDYH 360
LKTYKSVVPG SKLVDWLLAQ GDCQTREEAV ALGVGLCNNG FMHHVLEKSE FKDESQYFRF 420
HADEEMEGTS SKNKQLRNDF KLVENILAKR LLIPPQEDDY GFDLEEKNKA VVVKSVQRGS 480
LAEMAGLQAG RKIYSINEDL VFLRPFSEVE TILNQFFCSR RPLRLLVATK AKETIKVPDH 540
PEALSFQIRG TAPPCVFAVG RGSEAVAAGL CAGQCILKVN GTSVANDGAL EVLEHFQAFR 600
NHREEALGLY QWVYHSHEDA QLARASQGAP DEDPQEDDQP DSALPLLSLG PQLSLHEDSA 660
VVSLTLDNVH LEHGVVYEYM STAGAKCHVL EKIVEPRGCF RLAAKILEAF AVDDSIFVQN 720
CGRLMAMSSA IVTMSHYEFH NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQASLEPH 780
PLCGLDFCPT NCHVNLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG LNPMAYTQHC 840
ITTMAAPSWK CSPAVDEDSQ GQGLNDSSYG SASGAPSQQD RGLSFLLKQE DREIQDAYLQ 900
LFTKLDVALK EMKQYVTQIN RLLSTITEPT SAAPAPCDPS LVEETSSSPP VSEESEVDRT 960
DHSGIKKVCF KVSEDEQEDS GHDTMSYRDS YSECNSNRDS VLSYTSVRSN SSYLGSDEMG 1020
SGDELPCDMR IPSDKQDKLH GCLEHLFNQV DSIHALLKGP VMSRAFEETR HFPMKHSWQE 1080
FKQKEECTVR GRNLIQISIQ EDPWNLPSSI RTLVDNIQQY VEDGKNQLLL ALLKCTDTEL 1140
QLRRDAVFCQ ALVAAVCTFS EQLLAALDYR YNNNGEYEES SRDASRKWLE QVAATGVLLH 1200
WQSLLAPASV KEERTMLEDI WVTLSELDNV TFSFKQLDEN SVANTNVFYH IEGSRQALKV 1260
VFYLDGFHFS RLPSRLEGGA SLRLHTVLFT KALESVEGPP PPGNQAAEEL QQEINAQSLE 1320
KVQQYYRKLR AFYLERSNLP TDAGATAVKI DQLIRPINAL DELYRLMKTF VHPKAGAAGS 1380
LGAGLIPVSS ELCYRLGACQ ITMCGTGMQR STLSVSLEQA AILARSHGLL PKCVMQATDI 1440
MRKQGPRVEI LAKNLRIKDP MPQGAPRLYQ LCQPPVDGDL 1480 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0030833; P:regulation of actin filament polymerization; IEA:Compara.
 GO:0050773; P:regulation of dendrite development; IEA:Compara.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000591; DEP_dom.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR001478; PDZ.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00610; DEP
 PF00621; RhoGEF 
SMART
 SM00049; DEP
 SM00228; PDZ
 SM00233; PH 
PROSITE
 PS50186; DEP
 PS00741; DH_1
 PS50010; DH_2
 PS50106; PDZ
 PS50003; PH_DOMAIN 
PRINTS