Tag | Content |
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CPLM ID | CPLM-006574 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dynein heavy chain, cytoplasmic |
Protein Synonyms/Alias | Dynein heavy chain, cytosolic; DYHC |
Gene Name | DYN1 |
Gene Synonyms/Alias | DHC1; YKR054C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
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1026 | AQRHIRSKMDSWILY | ubiquitination | [1] | 1036 | SWILYVSKHLLTIYE | ubiquitination | [1] |
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Reference | [1] Identification, analysis, and prediction of protein ubiquitination sites. Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. Proteins. 2010 Feb 1;78(2):365-80. [ PMID: 19722269] |
Functional Description | Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle. |
Sequence Annotation | NP_BIND 1796 1803 ATP (Potential). NP_BIND 2074 2081 ATP (Potential). NP_BIND 2418 2425 ATP (Potential). NP_BIND 2760 2767 ATP (Potential). REGION 1 1757 Stem (By similarity). REGION 1758 1979 AAA 1 (By similarity). REGION 2036 2273 AAA 2 (By similarity). REGION 2379 2628 AAA 3 (By similarity). REGION 2722 2984 AAA 4 (By similarity). REGION 2993 3300 Stalk (By similarity). REGION 3370 3599 AAA 5 (By similarity). REGION 3760 3970 AAA 6 (By similarity). |
Keyword | 3D-structure; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Karyogamy; Microtubule; Motor protein; Nucleotide-binding; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4092 AA |
Protein Sequence | MCKNEARLAN ELIEFVAATV TGIKNSPKEN EQAFIDYLHC QYLERFQFFL GLLDGREFDT 60 LFVFLFEELD RTIVTIDIGE EAIYDANLAN KKYSTLLIIK SRSVIVDAEP IATQISAIYL 120 PGPVNAGNLA SIITHGVSSV FGQLIKSDTK TYSVETIDKT RRKLDDISKQ FQQLHTSIET 180 PDLLAMVPSI IKLAVSKGAT SHDYANYLPS NDLESMRFLN ILQSIANKWF LVLKQTLAID 240 RDIKNGSFLD EVEFWSNFYE VLKSLIEQTQ SQEFQVCLSV LTNAKRFHNL TNLLNEGSLS 300 DKFKLADKYN QFLSSIPIDE VRQASNLEDL QELFPVLASS LKKFRYSGYP VQRFVVLMDK 360 ISQEVMDAIL SNLSDLFQLE YGSFLGLYEK SAGMIEEWDD IVQDVNLLIR EDLRKRAPQE 420 LLIQKLTFTS ASVKATLDEI LSTRKRFFSL AETIKSISPS TYHEEIQRLY HPFEQIHDIS 480 VNFRLKLEQA ESEFSKNMLD LEKKLQNTLA SFMDSDHCPT EKLSYLVKFK PLMELCPRIK 540 VKVLENQQIL LLEIKKDIRQ LETGLELLPK ILHVEALNNI PPISARISYF LNVQSRIDNI 600 VQYLEALFGS NWNDTLEGRS ISTSIVQLRK ETNPHDVFLH WLGNFPEKAT ANLLTTPILK 660 LIRNNEDDYE LKVNFDFALA AAYSELRSLT YMAFQVPSHI VRIARTYMYL YPRAINLVEL 720 IQTFFSLSKS LSYTFYTNIF LKRNVQTVWL LLQQILITPW ESLQEESSEM SCSVHSLARL 780 EKSIDGILSD YQILKNSEPQ FAKEFSGLKS FDGTADDLHE VEEIISNIQA IFENLFTKGL 840 TNVSDHISTF NNLIISIILE KVRLNLKKMH FPKHVLKLSF NEGRITSSPS LAAMKRSLLK 900 DIEALLNKVV LINFLHDPDH PLSTTLTFNS LVIKLKDDIQ NCIEQVQNLH CKINSYVKEW 960 QKMEFLWQIT EEAFLEVVDN STQRCFGILK GLLDSQSKFD LIISRNNFSK NLVLHTEDAQ 1020 RHIRSKMDSW ILYVSKHLLT IYERDARKLH EDMNRDREAV EDMDINFTSL KNITVIIEAV 1080 NVNKRHLTER DIQIKLLGSV MRALTKLKVR FPSHFVYIDQ LDNDFSSLRQ SLSYVEQELQ 1140 KHRVVIAKSL EEGVENINNL SQSLNESWSV RKPISPTLTP PEALKILEFF NESITKLKKK 1200 MHSVAAAAKM LLIPVVLNDQ LTHVVEEVKT YDLVWRSIKN LWEDVQRTFE TPWCRVDVLL 1260 LQSDLANFLR RADELPRAVK QFEMYKSLFS QVNMLTSVNK ILVELKDGAL KPRHWNMIFR 1320 DIGKRQIQKN LLDKLEFSLK DVMVLNLTLN EILLTKIIER AQKEFVIEKS LNRIKKFWKE 1380 AQYEVIEHSS GLKLVREWDV LEQACKEDLE ELVSMKASNY YKIFEQDCLD LESKLTKLSE 1440 IQVNWVEVQF YWLDLYGILG ENLDIQNFLP LETSKFKSLT SEYKMITTRA FQLDTTIEVI 1500 HIPNFDTTLK LTIDSLKMIK SSLSTFLERQ RRQFPRFYFL GNDDLLKIIG SGKHHDQVSK 1560 FMKKMFGSIE SIIFLEDFIT GVRSVEGEVL NLNEKIELKD SIQAQEWLNI LDTEIKLSVF 1620 TQFRDCLGQL KDGTDIEVVV SKYIFQAILL SAQVMWTELV EKCLQTNQFS KYWKEVDMKI 1680 KGLLDKLNKS SDNVKKKIEA LLVEYLHFNN VIGQLKNCST KEEARLLWAK VQKFYQKNDT 1740 LDDLNSVFIS QSGYLLQYKF EYIGIPERLI YTPLLLIGFA TLTDSLHQKY GGCFFGPAGT 1800 GKTETVKAFG QNLGRVVVVF NCDDSFDYQV LSRLLVGITQ IGAWGCFDEF NRLDEKVLSA 1860 VSANIQQIQN GLQVGKSHIT LLEEETPLSP HTAVFITLNP GYNGRSELPE NLKKSFREFS 1920 MKSPQSGTIA EMILQIMGFE DSKSLASKIV HFLELLSSKC SSMNHYHFGL RTLKGVLRNC 1980 SPLISEFGEG EKTVVESLKR VILPSLGDTD ELVFKDELSK IFDSAGTPLN SKAIVQCLKD 2040 AGQRSGFSMS EEFLKKCMQF YYMQKTQQAL ILVGKAGCGK TATWKTVIDA MAIFDGHANV 2100 VYVIDTKVLT KESLYGSMLK ATLEWRDGLF TSILRRVNDD ITGTFKNSRI WVVFDSDLDP 2160 EYVEAMNSVL DDNKILTLPN GERLPIPPNF RILFETDNLD HTTPATITRC GLLWFSTDVC 2220 SISSKIDHLL NKSYEALDNK LSMFELDKLK DLISDSFDMA SLTNIFTCSN DLVHILGVRT 2280 FNKLETAVQL AVHLISSYRQ WFQNLDDKSL KDVITLLIKR SLLYALAGDS TGESQRAFIQ 2340 TINTYFGHDS QELSDYSTIV IANDKLSFSS FCSEIPSVSL EAHEVMRPDI VIPTIDTIKH 2400 EKIFYDLLNS KRGIILCGPP GSGKTMIMNN ALRNSSLYDV VGINFSKDTT TEHILSALHR 2460 HTNYVTTSKG LTLLPKSDIK NLVLFCDEIN LPKLDKYGSQ NVVLFLRQLM EKQGFWKTPE 2520 NKWVTIERIH IVGACNPPTD PGRIPMSERF TRHAAILYLG YPSGKSLSQI YEIYYKAIFK 2580 LVPEFRSYTE PFARASVHLY NECKARYSTG LQSHYLFSPR ELTRLVRGVY TAINTGPRQT 2640 LRSLIRLWAY EAWRIFADRL VGVKEKNSFE QLLYETVDKY LPNQDLGNIS STSLLFSGLL 2700 SLDFKEVNKT DLVNFIEERF KTFCDEELEV PMVIHESMVD HILRIDRALK QVQGHMMLIG 2760 ASRTGKTILT RFVAWLNGLK IVQPKIHRHS NLSDFDMILK KAISDCSLKE SRTCLIIDES 2820 NILETAFLER MNTLLANADI PDLFQGEEYD KLLNNLRNKT RSLGLLLDTE QELYDWFVGE 2880 IAKNLHVVFT ICDPTNNKSS AMISSPALFN RCIINWMGDW DTKTMSQVAN NMVDVIPMEF 2940 TDFIVPEVNK ELVFTEPIQT IRDAVVNILI HFDRNFYQKM KVGVNPRSPG YFIDGLRALV 3000 KLVTAKYQDL QENQRFVNVG LEKLNESVLK VNELNKTLSK KSTELTEKEK EARSTLDKML 3060 MEQNESERKQ EATEEIKKIL KVQEEDIRKR KEVVMKSIQD IEPTILEAQR GVKNIKKQQL 3120 TEIRSMVNPP SGVKIVMEAV CAILGYQFSN WRDIQQFIRK DDFIHNIVHY DTTLHMKPQI 3180 RKYMEEEFLS DPNFTYETIN RASKACGPLY QWVNAQINFS KVLENVDPLR QEMKRIEFES 3240 LKTKANLLAA EEMTQDLEAS IEVSKRKYSL LIRDVEAIKT EMSNVQANLD RSISLVKSLT 3300 FEKERWLNTT KQFSKTSQEL IGNCIISSIY ETYFGHLNER ERADMLVILK RLLGKFAVKY 3360 DVNYRFIDYL VTLDEKMKWL ECGLDKNDYF LENMSIVMNS QDAVPFLLDP SSHMITVISN 3420 YYGNKTVLLS FLEEGFVKRL ENAIRFGSVV IIQDGEFFDP IISRLISREF NHAGNRVTVE 3480 IGDHEVDVSG DFKLFIHSCD PSGDIPIFLR SRVRLVHFVT NKESIETRIF DITLTEENAE 3540 MQRKREDLIK LNTEYKLKLK NLEKRLLEEL NNSQGNMLEN DELMVTLNNL KKEAMNIEKK 3600 LSESEEFFPQ FDNLVEEYSI IGKHSVKIFS MLEKFGQFHW FYGISIGQFL SCFKRVFIKK 3660 SRETRAARTR VDEILWLLYQ EVYCQFSTAL DKKFKMIMAM TMFCLYKFDI ESEQYKEAVL 3720 TMIGVLSESS DGVPKLTVDT NNDLRYLWDY VTTKSYISAL NWFKNEFFVD EWNIADVVAN 3780 SENNYFTMAS ERDVDGTFKL IELAKASKES LKIIPLGSIE NLNYAQEEIS KSKIEGGWIL 3840 LQNIQMSLSW VKTYLHKHVE ETKAAEEHEK FKMFMTCHLT GDKLPAPLLQ RTDRFVYEDI 3900 PGILDTVKDL WGSQFFTGKI SGVWSVYCTF LLSWFHALIT ARTRLVPHGF SKKYYFNDCD 3960 FQFASVYLEN VLATNSTNNI PWAQVRDHIA TIVYGGKIDE EKDLEVVAKL CAHVFCGSDN 4020 LQIVPGVRIP QPLLQQSEEE ERARLTAILS NTIEPADSLS SWLQLPRESI LNYERLQAKE 4080 VASSTEQLLQ EM 4092 |
Gene Ontology | |
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