CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014442
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zyxin 
Protein Synonyms/Alias
  
Gene Name
 Zyx 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
24PAFYAPQKKFAPVVAacetylation[1, 2, 3]
25AFYAPQKKFAPVVAPacetylation[1]
35PVVAPKPKVNPFRPGacetylation[3]
256QAPTPAPKFAPVAPKacetylation[3]
263KFAPVAPKFTPVVSKacetylation[1, 2, 3]
270KFTPVVSKFSPGAPSacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
 Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). 
Sequence Annotation
 DOMAIN 376 435 LIM zinc-binding 1.
 DOMAIN 436 495 LIM zinc-binding 2.
 DOMAIN 496 562 LIM zinc-binding 3.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 144 144 Phosphoserine.
 MOD_RES 160 160 Phosphothreonine.
 MOD_RES 170 170 Phosphoserine (By similarity).
 MOD_RES 180 180 Phosphothreonine (By similarity).
 MOD_RES 265 265 Phosphothreonine (By similarity).
 MOD_RES 270 270 N6-acetyllysine (By similarity).
 MOD_RES 272 272 Phosphoserine (By similarity).
 MOD_RES 300 300 Phosphoserine (By similarity).
 MOD_RES 336 336 Phosphoserine.  
Keyword
 Acetylation; Cell adhesion; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 564 AA 
Protein Sequence
MAAPRPPPAI SVSVSAPAFY APQKKFAPVV APKPKVNPFR PGDSEPPVAA GAQRAQMGRV 60
GEIPPPPPED FPLPPPPLIG EGDDSEGALG GAFPPPPPPM IEEPFPPAPL EEDIFPSPPP 120
PLEEEGGPEA PTQLPPQPRE KVCSIDLEID SLSSLLDDMT KNDPFKARVS SGYVPPPVAT 180
PFVPKPSTKP APGGTAPLPP WKTPSSSQPP PQPQAKPQVQ LHVQPQAKPH VQPQPVSSAN 240
TQPRGPLSQA PTPAPKFAPV APKFTPVVSK FSPGAPSGPG PQPNQKMVPP DAPSSVSTGS 300
PQPPSFTYAQ QKEKPLVQEK QHPQPPPAQN QNQVRSPGGP GPLTLKEVEE LEQLTQQLMQ 360
DMEHPQRQSV AVNESCGKCN QPLARAQPAV RALGQLFHIT CFTCHQCQQQ LQGQQFYSLE 420
GAPYCEGCYT DTLEKCNTCG QPITDRMLRA TGKAYHPQCF TCVVCACPLE GTSFIVDQAN 480
QPHCVPDYHK QYAPRCSVCS EPIMPEPGRD ETVRVVALDK NFHMKCYKCE DCGKPLSIEA 540
DDNGCFPLDG HVLCRKCHSA RAQT 564 
Gene Ontology
 GO:0005913; C:cell-cell adherens junction; ISO:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 
Interpro
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS