CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001422
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sterol O-acyltransferase 2 
Protein Synonyms/Alias
 Acyl-coenzyme A:cholesterol acyltransferase 2; ACAT-2; Cholesterol acyltransferase 2 
Gene Name
 Soat2 
Gene Synonyms/Alias
 Acact-2; Acat2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
99TQELHPGKRKVFITRacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. 
Sequence Annotation
 ACT_SITE 437 437 Potential.  
Keyword
 Acyltransferase; Cholesterol metabolism; Complete proteome; Endoplasmic reticulum; Lipid metabolism; Membrane; Reference proteome; Steroid metabolism; Sterol metabolism; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 525 AA 
Protein Sequence
MQPKVPQLRR REGLGEEQEK GARGGEGNAR THGTPDLVQW TRHMEAVKTQ FLEQAQRELA 60
ELLDRALWEA MQAYPKQDRP LPSAAPDSTS KTQELHPGKR KVFITRKSLI DELMEVQHFR 120
TIYHMFIAGL CVLIISTLAI DFIDEGRLML EFDLLLFSFG QLPLALMTWV PMFLSTLLVP 180
YQTLWLWARP RAGGAWMLGA SLGCVLLAAH AVVLCVLPVH VSVRHELPPA SRCVLVFEQV 240
RLLMKSYSFL RETVPGIFCV RGGKGISPPS FSSYLYFLFC PTLIYRETYP RTPSIRWNYV 300
AKNFAQVLGC LLYACFILGR LCVPVFANMS REPFSTRALL LSILHATGPG IFMLLLIFFA 360
FLHCWLNAFA EMLRFGDRMF YRDWWNSTSF SNYYRTWNVV VHDWLYSYVY QDGLWLLGRR 420
ARGVAMLGVF LVSAVVHEYI FCFVLGFFYP VMLMLFLVFG GLLNFTMNDR HTGPAWNILM 480
WTFLFMGQGI QVSLYCQEWY ARRHCPLPQT TFWGMVTPRS WSCHP 525 
Gene Ontology
 GO:0005903; C:brush border; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0015485; F:cholesterol binding; IEA:Compara.
 GO:0034736; F:cholesterol O-acyltransferase activity; IEA:EC.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:Compara.
 GO:0004772; F:sterol O-acyltransferase activity; IDA:MGI.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0034435; P:cholesterol esterification; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IDA:MGI.
 GO:0034379; P:very-low-density lipoprotein particle assembly; IEA:Compara. 
Interpro
 IPR004299; MBOAT_fam.
 IPR014371; Oat_ACAT_DAG_ARE. 
Pfam
 PF03062; MBOAT 
SMART
  
PROSITE
  
PRINTS