CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042133
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
994EPDPGESKGESRSEMacetylation[1]
1196QTLCCYGKQLCTIPRacetylation[1]
1551NAKKKNNKKTNKNKSacetylation[1]
1552AKKKNNKKTNKNKSSacetylation[1]
1555KNNKKTNKNKSSISRacetylation[1]
1557NKKTNKNKSSISRANacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2320 AA 
Protein Sequence
DFGSLFDLEN DLPDELIPNG GGDLGILTSG NLVPDAASKH KQLSELLRGG TGSSINPGIG 60
NVSASSPVQQ GLGGQAQGQP NTTNMASLGA MGKSPLNQGD SSAASLPKQA ASTSGPTPPA 120
SQALNPQAQK QVGLVTSSPA TSQTGPGICM NANFNQTHPG LLNSSSGHSL MNQAQQGQAQ 180
VMNGSLGAAG RGRGAGMPYP APAMQGATSS VLAETLTQVS PQMAGHAGLN TAQAGGMTKM 240
GITGNTSPFG QPFSQTGGQQ MGATGVNPQL SSKQSMVNSL PTFPADIKNT SVTSVPNMSQ 300
MQTSVGIVPT QAIAAGPTAD PEKRKLIQQQ LVLLLHAHKC QRREQANGEV RACSLPHCRT 360
MKNVLNHMTH CQAGKACQVI VAHCASSRQI ISHWKNCTRH DCPVCLPLKN ASDKRNQQTI 420
LGSPASGIQN TIGSVGAGQQ NATSLSNPNP IDPSSMQRAY AALGLPYMNQ PQTQLQPQVP 480
GQQPAQPPAH QQMRTLNPLG NNPMNIPAGG ITTDQQPPNL ISESALPTSL GATNPLMNDG 540
SNSGNIGSLS TIPTAAPPSS TGVRKGWHEH VTQDLRSHLV HKLVQAIFPT PDPAALKDRR 600
MENLVAYAKK VEGDMYESAN SRDEYYHLLA EKIYKIQKEL EEKRRSRLHK QGILGNQPTL 660
PAPGAQAPVI PPAQSVRPPN IDGPLPLPVN RMQVSQGMNS FNPMSLGNVQ LPQAPMGPRA 720
ASPMNHSVQM NSMASVPGMA ISPSRMPQPP NMLGTHTNNM MAQAPAQNQF LPQSQFSSSS 780
GAISVNSVGM GQPAAQTAVS QGQVPGAALP NPLNMLGPQA SQLPCPPVTQ SPLHPTPPPA 840
STAAGMPSLQ HPTPPGMTPP QPAAPTQPST PVSSSGQTPT PTPGSVPSAT QTQSTPTVQA 900
AAQVTPQPQT PVQPPSVATP QSSQQQQQPT PVHAQPPGTP LSQAAASIDN RVPTPSSVTS 960
AETNSQQPGP DVPVLEMKAE MQAEDTEPDP GESKGESRSE MMEEDLQGSS QVKEETDTVE 1020
QKSEPMEVDE KKPEIKVEAK EEEESSTNGT ASQSTSPSQP RKKIFKPEEL RQALMPTLEA 1080
LYRQDPESLP FRQPVDPQLL GIPDYFDIVK NPMDLSTIKR KLDTGQYQEP WQYVDDVWLM 1140
FNNAWLYNRK TSRVYKFCSK LAEVFEQEID PVMQSLGYCC GRKYEFSPQT LCCYGKQLCT 1200
IPRDAAYYSY QNRYHFCEKC FTEIQGENVT LGDDPSQPQT TLNKDNFQGS VYDTLDPEPF 1260
VDCKECGRKM HQICVLHYDI IWPSGFVCDN CLKKTGRPRK ENKFSAKRLQ TTRLGNHLED 1320
RVNKFLRRQN HPEAGEVFVR VVASSDKTVE VKPGMKSRFV DSGEMSESFP YRTKALFAFE 1380
EIDGVDVCFF GMHVQEYGSD CPHPNRRVYI SYLDSIHFFR PRCLRTAVYH EILIGYLEYV 1440
KKLGYVTGHI WACPPSEGDD YIFHCHPPDQ KIPKPKRLQE WYKKMLDKAF AERIIHDYKD 1500
IFKQATEDRL TSAKELPYFE GDFWPNVFTA ASETPEGSQG DSKNAKKKNN KKTNKNKSSI 1560
SRANKKKPSM PNVSNDLSQK LYATMEKHKE VFFVIHLHAG PVINTLPPIV DPDPLLSCDL 1620
MDGRDAFLTL ARDKHWEFSS LRRSKWSTLC MLVELHTQGQ DRFVYTCNEC KHHVETRWHC 1680
TVCEDYDLCI NCYNTKSHTH KMVKWGLGLD DEGSSQGEPQ SKSPQESRRL SIQRCIQSLV 1740
HACQCRNANC SLPSCQKMKR VVQHTKGCKR KTNGGCPVCK QLIALCCYHA KHCQENKCPV 1800
PFCLNIKHKL RQQQIQHRLQ QAQLMRRRMA TMNTRNVPQQ SLPSPTSAPP EPSPVSMSPA 1860
GFSSVTRTQP PMTVSAGKPT NQVQAPPPPA QPPPAAVEAA RQIEREAQQQ QHLYRVNINN 1920
GMPPGRTSMG TPGSQMAPVG LNVPRPNQVS GPVMPSMQPG QWQQAPIPQQ QTMAGMPRPV 1980
MSMQAQAAVA GPRMPSVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA 2040
FIKQRTAKYV AIQNLNAMQA GVPRPSVPPQ QQAMGGLTPQ GQALNIMNPG HNPNMASMNP 2100
QYREMLRRQL QGNASMAGSM AGHNQFQQPQ GPGGYAPAMQ QQRMQQHLPI QGSSMGQMAA 2160
QMGQLGQMGQ PGLGADSTPN IQQALQQRIL QQQQMKQQIG SPGQPNPMSP QQHLLSGQPQ 2220
ASHLPGQQIT TSLSNQVHSS PSPRIQPQPS PHHVSPQTGS PHPGLAVTMA SSMDQGHLGN 2280
PEQSAMLPQL NTPNRSALSS ELSLVGDTTG DTLEKFVEGL 2320 
Gene Ontology
 GO:0000940; C:condensed chromosome outer kinetochore; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000123; C:histone acetyltransferase complex; IEA:Compara.
 GO:0016604; C:nuclear body; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0004402; F:histone acetyltransferase activity; IEA:Compara.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IEA:Compara.
 GO:0001191; F:RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030718; P:germ-line stem cell maintenance; IEA:Compara.
 GO:0018076; P:N-terminal peptidyl-lysine acetylation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR010303; DUF902_CREBbp.
 IPR013178; Histone_H3-K56_AcTrfase_RTT109.
 IPR003101; KIX_dom.
 IPR009110; Nuc_rcpt_coact.
 IPR014744; Nuc_rcpt_coact_CREBbp.
 IPR000197; Znf_TAZ.
 IPR000433; Znf_ZZ. 
Pfam
 PF00439; Bromodomain
 PF09030; Creb_binding
 PF06001; DUF902
 PF08214; KAT11
 PF02172; KIX
 PF02135; zf-TAZ
 PF00569; ZZ 
SMART
 SM00297; BROMO
 SM00551; ZnF_TAZ
 SM00291; ZnF_ZZ 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50952; KIX
 PS50134; ZF_TAZ
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS
 PR00503; BROMODOMAIN.