UniProt Accession

 NTR2_YEAST; P36118; D6VX87 

Genbank Protein ID

 Z28247; BK006944 

Genbank Nucleotide ID

 CAA82094.1; DAA09177.1 

Protein Name

 Pre-mRNA-splicing factor NTR2 

Protein Synonyms/Alias

 Nineteen complex-related protein 2; NTC-related protein 2 

Gene Name

 NTR2 

Gene Synonyms/Alias

 YKR022C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
186	IRLNGGLKRNNEKEI	ubiquitination	[1]
229	SKRKIIEKAINEVPY	acetylation	[2]

Reference

 [1] A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis.
 Ziv I, Matiuhin Y, Kirkpatrick DS, Erpapazoglou Z, Leon S, Pantazopoulou M, Kim W, Gygi SP, Haguenauer-Tsapis R, Reis N, Glickman MH, Kleifeld O.
 Mol Cell Proteomics. 2011 May;10(5):M111.009753. [PMID: 21427232]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex. 

Sequence Annotation

 MOD_RES 40 40 Phosphoserine.
 MOD_RES 153 153 Phosphoserine.
 MOD_RES 197 197 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 322 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IDA:SGD.
 GO:0000390; P:spliceosomal complex disassembly; IDA:SGD. 

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