CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022175
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inactive ubiquitin thioesterase FAM105A 
Protein Synonyms/Alias
  
Gene Name
 FAM105A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
116PRNKLMRKAYEELFWubiquitination[1, 2, 3, 4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 DOMAIN 128 356 OTU.  
Keyword
 Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 356 AA 
Protein Sequence
MAATRSPTRA RERERSGAPA AGSDQVHSWM LATSQALDTV WRMAKGFVML AVSFLVAAIC 60
YFRRLHLYSG HKLKWWIGYL QRKFKRNLSV EAEVDLLSYC AREWKGETPR NKLMRKAYEE 120
LFWRHHIKCV RQVRRDNYDA LRSVLFQIFS QGISFPSWMK EKDIVKLPEK LLFSQGCNWI 180
QQYSFGPEKY TGSNVFGKLR KYVELLKTQW TEFNGIRDYH KRGSMCNTLF SDAILEYKLY 240
EALKFIMLYQ VTEVYEQMKT KKVIPSLFRL LFSRETSSDP LSFMMNHLNS VGDTCGLEQI 300
DMFILGYSLE VKIKVFRLFK FNSRDFEVCY PEEPLRDWPE ISLLTENDRH YHIPVF 356 
Gene Ontology
  
Interpro
 IPR023235; FAM105.
 IPR023236; FAM105A. 
Pfam
  
SMART
  
PROSITE
 PS50802; OTU 
PRINTS
 PR02055; PROTEINF105.
 PR02056; PROTEINF105A.