CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038922
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Involucrin 
Protein Synonyms/Alias
  
Gene Name
 Ivl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
362LDPKEKQKLHDPELHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Keratinization; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 570 AA 
Protein Sequence
MSHQHTVPVT VPAVVQESLK TVCSPAQTQQ EQTKQPTPYP AQCQVFTDTQ EKGFPKHEEK 60
EANPVKDLPE QESEHHQQPG PQKQQLQVKK PEQELQEQEL HSEKQQTPQE PQGLLCLGQQ 120
QQREPQEQEQ HLRQHQQPQQ ESQGQGLCLG QQQDVLAPQE LHMGQHQKEK LQEPELPLGQ 180
QQKTPEEQEL ILGEKQQKLH LVERHQEPQE QELHLGQKQK QQQPQEQELQ LVQHQKQKQH 240
EPELCLRKQQ QQESHERELH LGKQQHQESH EPELHLGKQQ HQESHEPELH LGKQQHQESC 300
EPELHLGEQQ HQEQQQHQES CEPELHLGKQ QHQETQESEL QLGKQQKPHE PDMVLDPKEK 360
QKLHDPELHL GKQQHQESQE SELQVEKKQH EKSPEPELHL GKQQELHEPD MTEDQKEKQS 420
LHEPELHLGK QQESHEPDMT EDQKEKQSLY ESELHLGKQQ EQQIEYEGYQ RSKSLNQLLK 480
QEKASRGQEL DDSHLEQEKE LLDQRLDQEL VNKDEQLERK KHKLENLTQK EKQIKQLVPS 540
TDRVQETQPI QPVKEDSLTT KKQQHSHEVQ 570 
Gene Ontology
 GO:0001533; C:cornified envelope; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005198; F:structural molecule activity; IEA:Compara.
 GO:0031424; P:keratinization; IEA:UniProtKB-KW.
 GO:0018149; P:peptide cross-linking; IEA:Compara.
 GO:0010224; P:response to UV-B; IEA:Compara. 
Interpro
 IPR002360; Involucrin.
 IPR009733; Involucrin2.
 IPR019743; Involucrin_CS.
 IPR019571; Involucrin_N. 
Pfam
 PF06994; Involucrin2
 PF10583; Involucrin_N 
SMART
  
PROSITE
 PS00795; INVOLUCRIN 
PRINTS