CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010462
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein delta homolog 1 
Protein Synonyms/Alias
 DLK-1; pG2; Fetal antigen 1; FA1 
Gene Name
 DLK1 
Gene Synonyms/Alias
 DLK 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
376IDMTTFSKEAGDEEIubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 May have a role in neuroendocrine differentiation. 
Sequence Annotation
 DOMAIN 24 55 EGF-like 1.
 DOMAIN 53 86 EGF-like 2.
 DOMAIN 88 125 EGF-like 3.
 DOMAIN 127 168 EGF-like 4.
 DOMAIN 170 206 EGF-like 5.
 DOMAIN 208 245 EGF-like 6.
 CARBOHYD 94 94 O-linked (GalNAc...).
 CARBOHYD 100 100 N-linked (GlcNAc...).
 CARBOHYD 143 143 O-linked (GalNAc...).
 CARBOHYD 163 163 O-linked (GalNAc...); partial.
 CARBOHYD 165 165 N-linked (GlcNAc...); partial; atypical.
 CARBOHYD 172 172 N-linked (GlcNAc...); partial; atypical.
 CARBOHYD 214 214 O-linked (GalNAc...).
 CARBOHYD 222 222 O-linked (GalNAc...); partial.
 CARBOHYD 251 251 O-linked (GalNAc...); partial.
 CARBOHYD 256 256 O-linked (GalNAc...).
 CARBOHYD 260 260 O-linked (GalNAc...); partial.
 DISULFID 26 37 By similarity.
 DISULFID 30 43 By similarity.
 DISULFID 45 54 By similarity.
 DISULFID 57 68 By similarity.
 DISULFID 63 74 By similarity.
 DISULFID 76 85 By similarity.
 DISULFID 92 103 By similarity.
 DISULFID 97 113 By similarity.
 DISULFID 115 124 By similarity.
 DISULFID 131 144 By similarity.
 DISULFID 138 156 By similarity.
 DISULFID 158 167 By similarity.
 DISULFID 174 185 By similarity.
 DISULFID 179 194 By similarity.
 DISULFID 196 205 By similarity.
 DISULFID 212 223 By similarity.
 DISULFID 217 233 By similarity.
 DISULFID 235 244 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 383 AA 
Protein Sequence
MTATEALLRV LLLLLAFGHS TYGAECFPAC NPQNGFCEDD NVCRCQPGWQ GPLCDQCVTS 60
PGCLHGLCGE PGQCICTDGW DGELCDRDVR ACSSAPCANN RTCVSLDDGL YECSCAPGYS 120
GKDCQKKDGP CVINGSPCQH GGTCVDDEGR ASHASCLCPP GFSGNFCEIV ANSCTPNPCE 180
NDGVCTDIGG DFRCRCPAGF IDKTCSRPVT NCASSPCQNG GTCLQHTQVS YECLCKPEFT 240
GLTCVKKRAL SPQQVTRLPS GYGLAYRLTP GVHELPVQQP EHRILKVSMK ELNKKTPLLT 300
EGQAICFTIL GVLTSLVVLG TVGIVFLNKC ETWVSNLRYN HMLRKKKNLL LQYNSGEDLA 360
VNIIFPEKID MTTFSKEAGD EEI 383 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0048706; P:embryonic skeletal system development; IEA:Compara.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Compara.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0009791; P:post-embryonic development; IEA:Compara. 
Interpro
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site. 
Pfam
 PF00008; EGF
 PF12661; hEGF 
SMART
 SM00181; EGF 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3 
PRINTS