| Tag | Content |
|---|
| CPLM ID | CPLM-009903 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transient receptor potential cation channel subfamily V member 5 |
Protein Synonyms/Alias | TrpV5; Calcium transport protein 2; CaT2; Epithelial calcium channel 1; ECaC1; Osm-9-like TRP channel 3; OTRPC3 |
Gene Name | Trpv5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 57 | NDMCTLKKLQHDQNC | ubiquitination | [1] | | 659 | VQEQLSEKQPSGTET | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). |
Sequence Annotation | REPEAT 72 101 ANK 1.
REPEAT 110 139 ANK 2.
REPEAT 156 185 ANK 3.
REPEAT 232 261 ANK 4.
REGION 591 595 Interaction with S100A10.
REGION 643 646 Involved in Ca(2+)-dependent inactivation
REGION 693 723 Involved in Ca(2+)-dependent inactivation |
Keyword | ANK repeat; Calcium; Calcium channel; Calcium transport; Calmodulin-binding; Cell membrane; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 723 AA |
Protein Sequence | MGAKTPWIQL QKLLNWWVRD QDWNQHVDQL HMLQQKSIWE SPLLRAAKEN DMCTLKKLQH 60
DQNCDFRQRG ALGETALHVA ALYDNLDAAI MLMEAAPYLV TESTLCEPFV GQTALHIAVM 120
NQNVNLVRAL LARGASASAR ATGSAFHRSS HNLIYYGEHP LSFAACVGSE EIVRLLIEHG 180
ADIRAQDSLG NTVLHILVLQ PNKTFACQMY NLLLSYDGGD HLKSLELVPN NQGLTPFKLA 240
GVEGNTVMFQ HLMQKRKRIQ WSFGPLTSSL YDLTEIDSWG EELSFLELVV SSKKKEARQI 300
LEQTPVKELV SLKWKKYGQP YFCLLGALYI FYMVCFTTCC VYRPLKFRDA NRTHVRDNTI 360
MEQKSLQEAY VTYQDKIRLV GELVTVIGAV IILLLEIPDI FRVGASRYFG QTVLGGPFHV 420
IIITYASLVL LTMAMRLTNV NGEVVPMSMA LVLGWCSVMY FARGFQMLGP FTIMIQKMIF 480
GDLLRFCWLM AMVILGFASA FYIIFQTEDP DNLGEFSDYP TAMFSTFELF LTIIDGPANY 540
RVDLPFMYSV TYATFAIIAT LLMLNLFIAM MGDTHWRVAQ ERDELWRAQV VATTVMLERK 600
MPRFLWPRSG ICGCEYGLGD RWFLRVEHHQ EQNPYRVLRY VEAFKSSDKE EVQEQLSEKQ 660
PSGTETGTLA RGSVVLQTPP LSRTTSLSSN SHRGWEILRR NTLGHLNLGL DPGEGDGEEI 720
YQF 723 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IDA:MGI. GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. GO:0005262; F:calcium channel activity; IDA:UniProtKB. GO:0006874; P:cellular calcium ion homeostasis; NAS:UniProtKB. GO:0051262; P:protein tetramerization; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |