CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009426
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase PP1-beta catalytic subunit 
Protein Synonyms/Alias
 PP-1B 
Gene Name
 Ppp1cb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
25VRGCRPGKIVQMTEAacetylation[1]
146CKRRFNIKLWKTFTDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). 
Sequence Annotation
 ACT_SITE 124 124 Proton donor (By similarity).
 METAL 63 63 Iron (By similarity).
 METAL 65 65 Iron (By similarity).
 METAL 91 91 Iron (By similarity).
 METAL 91 91 Manganese (By similarity).
 METAL 123 123 Manganese (By similarity).
 METAL 172 172 Manganese (By similarity).
 METAL 247 247 Manganese (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 316 316 Phosphothreonine (By similarity).  
Keyword
 Acetylation; Carbohydrate metabolism; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; Glycogen metabolism; Hydrolase; Iron; Manganese; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MADGELNVDS LITRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI 60
CGDIHGQYTD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL 120
RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIVDEKIFC CHGGLSPDLQ 180
SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL 240
DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDETLMC SFQILKPSEK 300
KAKYQYGGLN SGRPVTPPRT ANPPKKR 327 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0042587; C:glycogen granule; IDA:RGD.
 GO:0070688; C:MLL5-L complex; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0000164; C:protein phosphatase type 1 complex; IDA:RGD.
 GO:0072357; C:PTW/PP1 phosphatase complex; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0017018; F:myosin phosphatase activity; ISS:UniProtKB.
 GO:0050115; F:myosin-light-chain-phosphatase activity; ISS:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
 GO:0006470; P:protein dephosphorylation; IDA:RGD.
 GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.
 GO:0005979; P:regulation of glycogen biosynthetic process; IDA:RGD.
 GO:0005981; P:regulation of glycogen catabolic process; IDA:RGD. 
Interpro
 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 
Pfam
 PF00149; Metallophos 
SMART
 SM00156; PP2Ac 
PROSITE
 PS00125; SER_THR_PHOSPHATASE 
PRINTS
 PR00114; STPHPHTASE.