UniProt Accession

 TIM23_HUMAN; O14925; Q53FF8; Q5T1E6; Q6P5S5 

Genbank Protein ID

 AF030162; AY442341; AK223331; AL450342; BC062707; BC066951 

Genbank Nucleotide ID

 AAB84060.1; AAR14723.1; BAD97051.1; CAI14480.1; AAH62707.1; AAH66951.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim23 

Protein Synonyms/Alias

  

Gene Name

 TIMM23 

Gene Synonyms/Alias

 TIM23 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
68	ILPTGANKTRGRFEL	ubiquitination	[1]
101	NGLRLGLKETQNMAW	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0031305; C:integral to mitochondrial inner membrane; IDA:BHF-UCL.
 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; IDA:BHF-UCL.
 GO:0005758; C:mitochondrial intermembrane space; IDA:MGI.
 GO:0015450; F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome. 

Interpro

 IPR003397; Tim17/Tim22/Tim23/PMP24.
 IPR005681; Tim23. 

Pfam

 PF02466; Tim17 

SMART

  

PROSITE

  

PRINTS