CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006076
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynamin-like GTPase MGM1, mitochondrial 
Protein Synonyms/Alias
 Mitochondrial division and morphology protein 17; Mitochondrial genome maintenance protein 1; Dynamin-like GTPase MGM1 large isoform; l-MGM1; Dynamin-like GTPase MGM1 small isoform; s-MGM1 
Gene Name
 MGM1 
Gene Synonyms/Alias
 MDM17; YOR211C; YOR50-1 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
549DVLKLGIKEFQEKFHubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane. 
Sequence Annotation
 DOMAIN 780 872 GED.
 NP_BIND 217 224 GTP (Potential).
 NP_BIND 317 321 GTP (Potential).
 NP_BIND 385 388 GTP (Potential).  
Keyword
 Complete proteome; Direct protein sequencing; GTP-binding; Hydrolase; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Reference proteome; Signal-anchor; Transit peptide; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 881 AA 
Protein Sequence
MNASPVRLLI LRRQLATHPA ILYSSPYIKS PLVHLHSRMS NVHRSAHANA LSFVITRRSI 60
SHFPKIISKI IRLPIYVGGG MAAAGSYIAY KMEEASSFTK DKLDRIKDLG ESMKEKFNKM 120
FSGDKSQDGG HGNDGTVPTA TLIAATSLDD DESKRQGDPK DDDDEDDDDE DDENDSVDTT 180
QDEMLNLTKQ MIEIRTILNK VDSSSAHLTL PSIVVIGSQS SGKSSVLESI VGREFLPKGS 240
NMVTRRPIEL TLVNTPNSNN VTADFPSMRL YNIKDFKEVK RMLMELNMAV PTSEAVSEEP 300
IQLTIKSSRV PDLSLVDLPG YIQVEAADQP IELKTKIRDL CEKYLTAPNI ILAISAADVD 360
LANSSALKAS KAADPKGLRT IGVITKLDLV DPEKARSILN NKKYPLSMGY VGVITKTPSS 420
INRKHLGLFG EAPSSSLSGI FSKGQHGQSS GEENTNGLKQ IVSHQFEKAY FKENKKYFTN 480
CQVSTKKLRE KLIKILEISM SNALEPTSTL IQQELDDTSY LFKVEFNDRH LTPKSYLLNN 540
IDVLKLGIKE FQEKFHRNEL KSILRAELDQ KVLDVLATRY WKDDNLQDLS SSKLESDTDM 600
LYWHKKLELA SSGLTKMGIG RLSTMLTTNA ILKELDNILE STQLKNHELI KDLVSNTAIN 660
VLNSKYYSTA DQVENCIKPF KYEIDLEERD WSLARQHSIN LIKEELRQCN SRYQAIKNAV 720
GSKKLANVMG YLENESNLQK ETLGMSKLLL ERGSEAIFLD KRCKVLSFRL KMLKNKCHST 780
IEKDRCPEVF LSAVSDKLTS TAVLFLNVEL LSDFFYNFPI ELDRRLTLLG DEQVEMFAKE 840
DPKISRHIEL QKRKELLELA LEKIDSILVF KKSYKGVSKN L 881 
Gene Ontology
 GO:0031314; C:extrinsic to mitochondrial inner membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031304; C:intrinsic to mitochondrial inner membrane; IDA:SGD.
 GO:0030061; C:mitochondrial crista; IDA:SGD.
 GO:0097002; C:mitochondrial inner boundary membrane; IDA:SGD.
 GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISA:SGD.
 GO:0008053; P:mitochondrial fusion; IDA:UniProtKB.
 GO:0000002; P:mitochondrial genome maintenance; IDA:UniProtKB.
 GO:0007006; P:mitochondrial membrane organization; IDA:UniProtKB.
 GO:0000001; P:mitochondrion inheritance; IDA:UniProtKB. 
Interpro
 IPR022812; Dynamin.
 IPR001401; Dynamin_GTPase.
 IPR019762; Dynamin_GTPase_CS.
 IPR020850; GTPase_effector_domain_GED.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00350; Dynamin_N 
SMART
 SM00053; DYNc 
PROSITE
 PS00410; DYNAMIN
 PS51388; GED 
PRINTS
 PR00195; DYNAMIN.