| Tag | Content |
|---|
| CPLM ID | CPLM-002423 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NAD(P) transhydrogenase subunit alpha |
Protein Synonyms/Alias | Nicotinamide nucleotide transhydrogenase subunit alpha; Pyridine nucleotide transhydrogenase subunit alpha |
Gene Name | pntA |
Gene Synonyms/Alias | b1603; JW1595 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 21 | TRVAATPKTVEQLLK | acetylation | [1] | | 228 | GSGDGYAKVMSDAFI | acetylation | [1] | | 236 | VMSDAFIKAEMELFA | acetylation | [1] | | 336 | TNLVNLLKLLCKEKD | acetylation | [1] | | 342 | LKLLCKEKDGNITVD | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. |
Sequence Annotation | NP_BIND 120 122 NAD.
NP_BIND 195 197 NAD.
BINDING 175 175 NAD; via amide nitrogen.
BINDING 238 238 NAD.
BINDING 257 257 NAD; via carbonyl oxygen. |
Keyword | 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; NAD; NADP; Nucleotide-binding; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 510 AA |
Protein Sequence | MRIGIPRERL TNETRVAATP KTVEQLLKLG FTVAVESGAG QLASFDDKAF VQAGAEIVEG 60
NSVWQSEIIL KVNAPLDDEI ALLNPGTTLV SFIWPAQNPE LMQKLAERNV TVMAMDSVPR 120
ISRAQSLDAL SSMANIAGYR AIVEAAHEFG RFFTGQITAA GKVPPAKVMV IGAGVAGLAA 180
IGAANSLGAI VRAFDTRPEV KEQVQSMGAE FLELDFKEEA GSGDGYAKVM SDAFIKAEME 240
LFAAQAKEVD IIVTTALIPG KPAPKLITRE MVDSMKAGSV IVDLAAQNGG NCEYTVPGEI 300
FTTENGVKVI GYTDLPGRLP TQSSQLYGTN LVNLLKLLCK EKDGNITVDF DDVVIRGVTV 360
IRAGEITWPA PPIQVSAQPQ AAQKAAPEVK TEEKCTCSPW RKYALMALAI ILFGWMASVA 420
PKEFLGHFTV FALACVVGYY VVWNVSHALH TPLMSVTNAI SGIIVVGALL QIGQGGWVSF 480
LSFIAVLIAS INIFGGFTVT QRMLKMFRKN 510 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. GO:0051287; F:NAD binding; IDA:EcoCyc. GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IDA:UniProtKB. GO:0046983; F:protein dimerization activity; IDA:UniProtKB. GO:0006740; P:NADPH regeneration; IDA:UniProtKB. GO:0015992; P:proton transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |