CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010344
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-aminobutyraldehyde dehydrogenase 
Protein Synonyms/Alias
 1-pyrroline dehydrogenase; 4-aminobutanal dehydrogenase; ABALDH 
Gene Name
 prr 
Gene Synonyms/Alias
 ydcW; b1444; JW1439 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
183ITPLTALKLAELAKDacetylation[1]
299IYDTLVEKLGAAVATacetylation[2]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 
Functional Description
 Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency. 
Sequence Annotation
 NP_BIND 172 175 NAD.
 NP_BIND 225 231 NAD.
 ACT_SITE 246 246 By similarity.
 ACT_SITE 280 280 Nucleophile (Probable).
 BINDING 146 146 NAD; via carbonyl oxygen.
 BINDING 209 209 NAD.  
Keyword
 3D-structure; Complete proteome; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MQHKLLINGE LVSGEGEKQP VYNPATGDVL LEIAEASAEQ VDAAVRAADA AFAEWGQTTP 60
KVRAECLLKL ADVIEENGQV FAELESRNCG KPLHSAFNDE IPAIVDVFRF FAGAARCLNG 120
LAAGEYLEGH TSMIRRDPLG VVASIAPWNY PLMMAAWKLA PALAAGNCVV LKPSEITPLT 180
ALKLAELAKD IFPAGVINIL FGRGKTVGDP LTGHPKVRMV SLTGSIATGE HIISHTASSI 240
KRTHMELGGK APVIVFDDAD IEAVVEGVRT FGYYNAGQDC TAACRIYAQK GIYDTLVEKL 300
GAAVATLKSG APDDESTELG PLSSLAHLER VGKAVEEAKA TGHIKVITGG EKRKGNGYYY 360
APTLLAGALQ DDAIVQKEVF GPVVSVTPFD NEEQVVNWAN DSQYGLASSV WTKDVGRAHR 420
VSARLQYGCT WVNTHFMLVS EMPHGGQKLS GYGKDMSLYG LEDYTVVRHV MVKH 474 
Gene Ontology
 GO:0033737; F:1-pyrroline dehydrogenase activity; IMP:EcoCyc.
 GO:0019145; F:aminobutyraldehyde dehydrogenase activity; IDA:EcoCyc.
 GO:0042802; F:identical protein binding; IDA:EcoCyc.
 GO:0051287; F:NAD binding; IEA:HAMAP.
 GO:0009447; P:putrescine catabolic process; IDA:EcoCyc. 
Interpro
 IPR017749; 1-pyrroline_dehydrogenase.
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS