UniProt Accession

 GMFB_HUMAN; P60983; B2R499; P17774 

Genbank Protein ID

 M86492; AB001106; CR542113; AK311753; CH471061 

Genbank Nucleotide ID

 AAA58614.1; BAA19232.1; CAG46910.1; BAG34696.1; EAW80638.1 

Protein Name

 Glia maturation factor beta 

Protein Synonyms/Alias

 GMF-beta 

Gene Name

 GMFB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	LRKFRFRKETNNAAI	ubiquitination	[1]
35	NNAAIIMKIDKDKRL	ubiquitination	[2]
74	RFIVYSYKYQHDDGR	ubiquitination	[2]
97	FSSPVGCKPEQQMMY	ubiquitination	[3]
110	MYAGSKNKLVQTAEL	ubiquitination	[3]
119	VQTAELTKVFEIRNT	ubiquitination	[3, 4]
137	TEEWLREKLGFFH**	ubiquitination	[3]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 

Functional Description

 This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. 

Sequence Annotation

 DOMAIN 4 139 ADF-H.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 Acetylation; Complete proteome; Growth factor; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008047; F:enzyme activator activity; TAS:ProtInc.
 GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
 GO:0004871; F:signal transducer activity; TAS:ProtInc.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0006468; P:protein phosphorylation; TAS:ProtInc. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR011171; GMF-beta. 

Pfam

 PF00241; Cofilin_ADF 

SMART

 SM00102; ADF 

PROSITE

 PS51263; ADF_H 

PRINTS