UniProt Accession

 CMBL_HUMAN; Q96DG6; D3DTC7; Q8TED6 

Genbank Protein ID

 AJ278125; AK074197; CH471102; CH471102; BC001573 

Genbank Nucleotide ID

 CAC81950.1; BAB85014.1; EAX08070.1; EAX08071.1; AAH01573.1 

Protein Name

 Carboxymethylenebutenolidase homolog 

Protein Synonyms/Alias

  

Gene Name

 CMBL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	HIKAYVTKSPVDAGK	acetylation	[1]
36	HIKAYVTKSPVDAGK	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. 

Sequence Annotation

 ACT_SITE 132 132
 ACT_SITE 179 179 By similarity.
 ACT_SITE 212 212 By similarity.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 36 36 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 

Interpro

 IPR002925; Dienelactn_hydro. 

Pfam

 PF01738; DLH 

SMART

  

PROSITE

  

PRINTS