CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017900
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell adhesion molecule 1 
Protein Synonyms/Alias
 Immunoglobulin superfamily member 4; IgSF4; Nectin-like protein 2; NECL-2; Spermatogenic immunoglobulin superfamily; SgIgSF; Synaptic cell adhesion molecule; SynCAM; Tumor suppressor in lung cancer 1; TSLC-1 
Gene Name
 Cadm1 
Gene Synonyms/Alias
 Igsf4; Necl2; Ra175; Syncam; SynCam1; Tslc1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
387TYFTHEAKGADDAADubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. 
Sequence Annotation
 DOMAIN 48 142 Ig-like V-type.
 DOMAIN 147 241 Ig-like C2-type 1.
 DOMAIN 246 332 Ig-like C2-type 2.
 MOD_RES 448 448 Phosphoserine.
 CARBOHYD 70 70 N-linked (GlcNAc...).
 CARBOHYD 104 104 N-linked (GlcNAc...).
 CARBOHYD 116 116 N-linked (GlcNAc...).
 CARBOHYD 168 168 N-linked (GlcNAc...).
 CARBOHYD 304 304 N-linked (GlcNAc...); atypical.
 CARBOHYD 307 307 N-linked (GlcNAc...).
 CARBOHYD 311 311 N-linked (GlcNAc...).
 DISULFID 67 127 By similarity.
 DISULFID 169 223 By similarity.
 DISULFID 270 316 By similarity.  
Keyword
 Alternative splicing; Apoptosis; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Spermatogenesis; Synapse; Transmembrane; Transmembrane helix; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 456 AA 
Protein Sequence
MASAVLPSGS QCAAAAAVAA AAAPPGLRLR LLLLLLSAAA LIPTGDGQNL FTKDVTVIEG 60
EVATISCQVN KSDDSVIQLL NPNRQTIYFR DFRPLKDSRF QLLNFSSSEL KVSLTNVSIS 120
DEGRYFCQLY TDPPQESYTT ITVLVPPRNL MIDIQKDTAV EGEEIEVNCT AMASKPATTI 180
RWFKGNKELK GKSEVEEWSD MYTVTSQLML KVHKEDDGVP VICQVEHPAV TGNLQTQRYL 240
EVQYKPQVHI QMTYPLQGLT REGDAFELTC EAIGKPQPVM VTWVRVDDEM PQHAVLSGPN 300
LFINNLNKTD NGTYRCEASN IVGKAHSDYM LYVYDSRAGE EGTIGAVDHA VIGGVVAVVV 360
FAMLCLLIIL GRYFARHKGT YFTHEAKGAD DAADADTAII NAEGGQNNSE EKKEYFI 417 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008021; C:synaptic vesicle; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0060348; P:bone development; IMP:MGI.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0016338; P:calcium-independent cell-cell adhesion; IDA:MGI.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0008037; P:cell recognition; IDA:UniProtKB.
 GO:0051606; P:detection of stimulus; IDA:UniProtKB.
 GO:0007157; P:heterophilic cell-cell adhesion; IDA:UniProtKB.
 GO:0007156; P:homophilic cell adhesion; IDA:UniProtKB.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0050715; P:positive regulation of cytokine secretion; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
 GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IDA:UniProtKB.
 GO:0007416; P:synapse assembly; IDA:MGI.
 GO:0009826; P:unidimensional cell growth; IMP:MGI. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set.
 IPR003585; Neurexin-like. 
Pfam
 PF08205; C2-set_2
 PF07686; V-set 
SMART
 SM00294; 4.1m
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS