CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025616
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 EIF4G1 variant protein 
Protein Synonyms/Alias
  
Gene Name
 EIF4G1 variant protein 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
618NIQPGEQKYEYKSDQubiquitination[1]
795RVRSILNKLTPQMFQubiquitination[1]
857LKVPTTEKPTVTVNFubiquitination[1]
925RRSLGNIKFIGELFKubiquitination[1]
932KFIGELFKLKMLTEAubiquitination[1]
1099SRLTKITKPGSIDSNubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1624 AA 
Protein Sequence
APLFPNRCWG DPDVAPNEMN KAPQSTGPPP APSPGLPQPA FPPGQTAPVV FSTPQATQMN 60
TPSQPRQGGF RSLQHFYPSR AQPPSSAASR VQSAAPARPG PAAHVYPAGS QVMMIPSQIS 120
YPASQGAYYI PGQGRSTYVV PTQQYPVQPG APGFYPGASP TEFGTYAGAY YPAQGVQQFP 180
TGVAPAPVLM NQPPQIAPKR ERKTIRIRDP NQGGKDITEE IMSGARTAST PTPPQTGGGL 240
EPQANGETPQ VAVIVRPDDR SQGAIIADRP GLPGPEHSPS ESQPSSPSPT PSPSPVLEPG 300
SEPNLAVLSI PGDTMTTIQM SVEESTPISR ETGEPYRLSP EPTPLAEPIL EVEVTLSKPV 360
PESEFSSSPL QAPTPLASHT VEIHEPNGMV PSEDLEPEVE SSPELAPPPA CPSESPVPIA 420
PTAQPEELLN GAPSPPAVDL SPVSEPEEQA KEVTASVAPP TIPSATPATA PSATSPAQEE 480
EMEEEEEEEE GEAGEAGEAE SEKGGEELLP PESTPIPANL SQNLEAAAAT QVAVSVPKRR 540
RKIKELNKKE AVGDLLDAFK EANPAVPEVE NQPPAGSNPG PESEGSGVPP RPEEADETWD 600
SKEDKIHNAE NIQPGEQKYE YKSDQWKPLN LEEKKRYDRE FLLGFQFIFA SMQKPEGLPH 660
ISDVVLDKAN KTPLRPLDPT RLQGINCGPD FTPSFANLGR TTLSTRGPPR GGPGGELPRG 720
PAGLGPRRSQ QGPRKEPRKI IATVLMTEDI KLNKAEKAWK PSSKRTAADK DRGEEDADGS 780
KTQDLFRRVR SILNKLTPQM FQQLMKQVTQ LAIDTEERLK GVIDLIFEKA ISEPNFSVAY 840
ANMCRCLMAL KVPTTEKPTV TVNFRKLLLN RCQKEFEKDK DDDEVFEKKQ KEMDEAATAE 900
ERGRLKEELE EARDIARRRS LGNIKFIGEL FKLKMLTEAI MHDCVVKLLK NHDEESLECL 960
CRLLTTIGKD LDFEKAKPRM DQYFNQMEKI IKEKKTSSRI RFMLQDVLDL RGSNWVPRRG 1020
DQGPKTIDQI HKEAEMEEHR EHIKVQQLMA KGSDKRRGGP PGPPISRGLP LVDDGGWNTV 1080
PISKGSRPID TSRLTKITKP GSIDSNNQLF APGGRLSWGK GSSGGSGAKP SDAASEAARP 1140
ATSTLNRFSA LQQAVPTEST DNRRVVQRSS LSRERGEKAG DRGDRLERSE RGGDRGDRLD 1200
RARTPATKRS FSKEVEERSR ERPSQPEGLR KAASLTEDRD RGRDAVKREA ALPPVSPLKA 1260
ALSEEELEKK SKAIIEEYLH LNDMKEAVQC VQELASPSLL FIFVRHGVES TLERSAIARE 1320
HMGQLLHQLL CAGHLSTAQY YQGLYEILEL AEDMEIDIPH VWLYLAELVT PILQEGGVPM 1380
GELFREITKP LRPLGKAASL LLEILGLLCK SMGPKKVGTL WREAGLSWKE FLPEGQDIGA 1440
FVAEQKVEYT LGEESEAPGQ RALPSEELNR QLEKLLKEGS SNQRVFDWIE ANLSEQQIVS 1500
NTLVRALMTA VCYSAIIFET PLRVDVAVLK ARAKLLQKYL CDEQKELQAL YALQALVVTL 1560
EQPPNLLRMF FDALYDEDVV KEDAFYSWES SKDPAEQQGK GVALKSVTAF FKWLREAEEE 1620
SDHN 1624 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003891; Initiation_fac_eIF4g_MI.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3.
 IPR003307; W2_domain. 
Pfam
 PF02847; MA3
 PF02854; MIF4G
 PF02020; W2 
SMART
 SM00515; eIF5C
 SM00544; MA3
 SM00543; MIF4G 
PROSITE
 PS51366; MI
 PS51363; W2 
PRINTS