UniProt Accession

 LMBD1_HUMAN; Q9NUN5; A8K204; E1P531; Q5VUN6; Q86Y70; Q96FW4; Q9BY56; Q9NZD6 

Genbank Protein ID

 AY136817; AF113224; AF208863; AK002102; AK290069; AL583831; AL358133; AL590702; AL583831; AL358133; AL590702; AL358133; AL583831; AL590702; AL358133; AL583831; AL590702; AL590702; AL358133; AL583831; AL590702; AL358133; AL583831; CH471051; CH471051; CH471051; BC010360; BC047073; AF211480 

Genbank Nucleotide ID

 AAN11301.1; AAG39295.1; AAF64277.1; BAA92087.1; BAF82758.1; CAH74081.1; CAH74081.1; CAH74081.1; CAH74083.1; CAH74083.1; CAH74083.1; CAI16835.1; CAI16835.1; CAI16835.1; CAI16836.1; CAI16836.1; CAI16836.1; CAI17314.1; CAI17314.1; CAI17314.1; CAI17316.1; CAI17316.1; CAI17316.1; EAW48832.1; EAW48833.1; EAW48835.1; AAH10360.1; AAH47073.1; AAK26247.1 

Protein Name

 Probable lysosomal cobalamin transporter 

Protein Synonyms/Alias

 HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein 

Gene Name

 LMBRD1 

Gene Synonyms/Alias

 C6orf209; NESI; BM-021; CD001; MSTP044 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
252	EQHIQTIKSKSKDGR	ubiquitination	[1]
254	HIQTIKSKSKDGRPL	ubiquitination	[2]
256	QTIKSKSKDGRPLPA	ubiquitination	[3]
270	ARDKRALKQFEERLR	ubiquitination	[2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV). 

Sequence Annotation

 MOD_RES 238 238 Phosphothreonine (By similarity).
 MOD_RES 528 528 Phosphoserine.
 MOD_RES 531 531 Phosphoserine.
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 CARBOHYD 88 88 N-linked (GlcNAc...) (Potential).
 CARBOHYD 170 170 N-linked (GlcNAc...) (Potential).
 CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
 CARBOHYD 448 448 N-linked (GlcNAc...) (Potential).
 CARBOHYD 457 457 N-linked (GlcNAc...) (Probable).  

Keyword

 Alternative splicing; Cobalamin; Cobalt; Complete proteome; Glycoprotein; Host-virus interaction; Lysosome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 540 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR006876; LMBR1-like_membr_prot. 

Pfam

 PF04791; LMBR1 

SMART

  

PROSITE

  

PRINTS