UniProt Accession

 LEG3_RAT; P08699 

Genbank Protein ID

 J02962; BC089054; M13697 

Genbank Nucleotide ID

 AAA40828.1; AAH89054.1; AAA41378.1 

Protein Name

 Galectin-3 

Protein Synonyms/Alias

 Gal-3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; IgE-binding protein; Laminin-binding protein; Lectin L-29; Mac-2 antigen 

Gene Name

 Lgals3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
208	AFPFESGKPFKIQVL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity). Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. 

Sequence Annotation

 REPEAT 35 43 1.
 REPEAT 44 52 2.
 REPEAT 53 61 3.
 REPEAT 62 70 4.
 REPEAT 71 79 5.
 REPEAT 80 88 6.
 REPEAT 89 98 7; approximate.
 REPEAT 99 105 8; approximate.
 REPEAT 106 112 9; truncated.
 DOMAIN 130 260 Galectin.
 REGION 35 112 9 X 9 AA tandem repeats of Y-P-G-X(3)-P-
 REGION 193 199 Beta-galactoside binding (By similarity).
 MOTIF 238 253 Nuclear export signal (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 6 6 Phosphoserine; by CK1 (By similarity).
 DISULFID 185 185 Interchain (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Disulfide bond; IgE-binding protein; Immunity; Innate immunity; Lectin; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 262 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005578; C:proteinaceous extracellular matrix; IEA:Compara.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0001501; P:skeletal system development; IEA:Compara. 

Interpro

 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR015534; Galectin_3.
 IPR001079; Galectin_CRD. 

Pfam

 PF00337; Gal-bind_lectin 

SMART

 SM00908; Gal-bind_lectin
 SM00276; GLECT 

PROSITE

 PS51304; GALECTIN 

PRINTS