UniProt Accession

 DNJB6_RAT; Q6AYU3 

Genbank Protein ID

 BC078908 

Genbank Nucleotide ID

 AAH78908.1 

Protein Name

 DnaJ homolog subfamily B member 6 

Protein Synonyms/Alias

 Heat shock protein J2; HSJ-2; Hsp40 homolog; MRJ; MSJ-1 

Gene Name

 Dnajb6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
60	YEVLSDAKKRDIYDK	ubiquitination	[1]
61	EVLSDAKKRDIYDKY	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). 

Sequence Annotation

 DOMAIN 3 69 J.
 REGION 2 147 Interaction with HSP70 (By similarity).
 REGION 120 243 Interaction with KRT18 (By similarity).  

Keyword

 Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IEA:UniProtKB-SubCell. 

Interpro

 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS. 

Pfam

 PF00226; DnaJ 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2 

PRINTS

 PR00625; JDOMAIN.