| Tag | Content |
|---|
| CPLM ID | CPLM-017978 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC1 domain family member 15 |
Protein Synonyms/Alias | GTPase-activating protein RAB7; GAP for RAB7; Rab7-GAP |
Gene Name | TBC1D15 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 34 | YIHSSCGKTNDQDGL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). |
Sequence Annotation | DOMAIN 346 556 Rab-GAP TBC.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 70 70 Phosphoserine.
MOD_RES 180 180 Phosphotyrosine (By similarity).
MOD_RES 205 205 Phosphoserine (By similarity).
MOD_RES 675 675 Phosphoserine.
MOD_RES 689 689 Phosphothreonine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; GTPase activation; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 691 AA |
Protein Sequence | MCPGLYPYSS LLEYGRSMII YEQEGVYIHS SCGKTNDQDG LISGILRVLE KDAEVIVDWR 60
PLDDALDSSS ILYARKDSSS VVEWTQAPKE RGHRGSEHLN SYEAEWDMVN TVSFKRKPHT 120
NGDAPSHRNG KSKWSFLFSL TDLKSIKQNK EGMGWSYLVF CLKDDVVLPA LHFHQGDSKL 180
LIESLEKYVV LCESPQDKRT LLVNCQNKSL SQSFENLLDE PAYGLIQKIK KDPYTATMIG 240
FSKVTNYIFD SLRGSDPSTH QRPPSEMADF LSDAIPGLKI NQQEEPGFEV ITRIDLGERP 300
VVQRREPVSL EEWTKNIDSE GRILNVDNMK QMIFRGGLSH ALRKQAWKFL LGYFPWDSTK 360
EERTQLQKQK TDEYFRMKLQ WKSISQEQEK RNSRLRDYRS LIEKDVNRTD RTNKFYEGQD 420
NPGLILLHDI LMTYCMYDFD LGYVQGMSDL LSPLLYVMEN EVDAFWCFAS YMDQMHQNFE 480
EQMQGMKTQL IQLSTLLRLL DSGFCSYLES QDSGYLYFCF RWLLIRFKRE FSFLDILRLW 540
EVMWTELPCT NFHLLLCCAI LESEKQQIME KHYGFNEILK HINELSMKID VEDILCKAEA 600
ISLQMVKCKE LPQAVCEILG LQGSEVTTPD SDVGEDENVV MTPCPTSAFQ SNALPTLSAS 660
GARNDSPTQI PVSSDVCRLT PA 682 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |