CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007276
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-dependent ATPase MGS1 
Protein Synonyms/Alias
 Maintenance of genome stability protein 1 
Gene Name
 MGS1 
Gene Synonyms/Alias
 YNL218W; N1302 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
64RKQANSEKFIDLENKacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Involved in the maintenance of proper DNA topology and chromosome integrity via annealing of single-stranded DNA breaks. Modulates DNA polymerase delta during replication or replication- associated repair. May function as a modulator for SGS1 when DNA is damaged. 
Sequence Annotation
 ZN_FING 11 34 UBZ-type.
 NP_BIND 177 184 ATP (Potential).  
Keyword
 ATP-binding; Complete proteome; DNA-binding; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 587 AA 
Protein Sequence
MSNKRTSVEQ LISCPICSRK VFFSLINSHL DICGKEKSKP SSRPQTVSSL LAGPKKRKQA 60
NSEKFIDLEN KDHEIKPGLK SESDDIEIVE NESKRFKAAP STDFAKSIVE PASSRDQLHN 120
DYESRWLQKI SHLPLSEKLR PKELRDYVGQ QHILSQDNGT LFKYIKQGTI PSMILWGPPG 180
VGKTSLARLL TKTATTSSNE SNVGSRYFMI ETSATKANTQ ELRGIFEKSK KEYQLTKRRT 240
VLFIDEIHRF NKVQQDLLLP HVENGDIILI GATTENPSFQ LNNALISRCL IFVLEKLNVN 300
ELCIVLSRGI ALLNKCRKQV WNIENPLKLS RSILEYVVDL SVGDTRRALN MLEMIEVSTR 360
ERKADEEELS IDDVRDIIKN NSSNGLNTYY DPKGDNHYDT ISAFHKSIRG GDENASLYYL 420
ARMLQGGEDP LYVARRMIRI ASEDIGLRDS SLLPLAVAAH DAVMKVGLPE ADLALAQCCV 480
ALARAPKSVE LYRAWKKLRA MMSENMYSLA SSEIPMHIRN APTKLMEELG YHKGYKYNPD 540
YIEGKVQQDY FPKEVLEKCP NKTDLKFLDG KHLGDKEDPD LRQSYQG 587 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008047; F:enzyme activator activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043142; F:single-stranded DNA-dependent ATPase activity; IDA:SGD.
 GO:0043130; F:ubiquitin binding; ISS:SGD.
 GO:0006952; P:defense response; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0033567; P:DNA replication, Okazaki fragment processing; IDA:SGD.
 GO:0000733; P:DNA strand renaturation; IDA:SGD.
 GO:0006282; P:regulation of DNA repair; IGI:SGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR000767; Disease_R.
 IPR021886; MgsA_C.
 IPR027417; P-loop_NTPase.
 IPR006642; Znf_Rad18_put. 
Pfam
 PF00004; AAA
 PF12002; MgsA_C 
SMART
 SM00382; AAA
 SM00734; ZnF_Rad18 
PROSITE
 PS00674; AAA 
PRINTS
 PR00364; DISEASERSIST.