CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009949
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 55 kDa erythrocyte membrane protein 
Protein Synonyms/Alias
 p55; Membrane protein, palmitoylated 1 
Gene Name
 Mpp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
29YLEHLLQKRNRPETSubiquitination[1]
76VRLIQFEKITEEPMGubiquitination[1]
91ITLKLNEKQSCTVARubiquitination[1]
135HSVDQLQKAMKETKGubiquitination[1]
141QKAMKETKGMISLKVubiquitination[1]
185PCKEAGLKFVTGDIIubiquitination[1]
212GRVEGSSKESAGLIPubiquitination[1]
329KKSEEDGKEYHFISTubiquitination[1]
371ETVHQIHKQDKIAILubiquitination[1]
444NSVDETLKKLQEAFDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity. 
Sequence Annotation
 DOMAIN 71 152 PDZ.
 DOMAIN 158 228 SH3.
 DOMAIN 282 451 Guanylate kinase-like.
 REGION 268 466 Interaction with MPP5 (By similarity).
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 49 49 Phosphothreonine (By similarity).
 MOD_RES 57 57 Phosphoserine (By similarity).
 MOD_RES 110 110 Phosphoserine (By similarity).
 MOD_RES 243 243 Phosphoserine (By similarity).  
Keyword
 Cell projection; Complete proteome; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 466 AA 
Protein Sequence
MTLKSSEGEG GNSMRTALSD LYLEHLLQKR NRPETSLNQS NVTTEDMYTN GSPAPGSPAH 60
AKGQEARRVR LIQFEKITEE PMGITLKLNE KQSCTVARIL HGGMIHRQGS LHVGDEILEI 120
NGTNVTNHSV DQLQKAMKET KGMISLKVIA NQQSRLPALQ MFMRAQFDYD PQKDNLIPCK 180
EAGLKFVTGD IIQIINKDDS NWWQGRVEGS SKESAGLIPS PELQEWRVAS VAHSAPSEAP 240
SCSPFGKKKK CKDKYLAKHS SIFDQLDVVS YEEVVRLPAF KRKTLVLIGA SGVGRSHIKN 300
GLLSHNPEKF AYPAPYTTRP PKKSEEDGKE YHFISTEEMT KNISANEFLE FGSYQGNMFG 360
TKFETVHQIH KQDKIAILDI EPQTLKTVRT AELSPFIVFI APTDQGTQTE ALQQLQKDSE 420
AIRSQYAHYF DLSLVNNSVD ETLKKLQEAF DQACSSPQWV PVSWVY 466 
Gene Ontology
 GO:0030863; C:cortical cytoskeleton; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
 GO:0090022; P:regulation of neutrophil chemotaxis; IMP:UniProtKB. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF00595; PDZ
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 
PRINTS