| Tag | Content |
|---|
| CPLM ID | CPLM-002762 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Stromelysin-2 |
Protein Synonyms/Alias | SL-2; Matrix metalloproteinase-10; MMP-10; Transin-2 |
Gene Name | MMP10 |
Gene Synonyms/Alias | STMY2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 54 | DVKQFRRKDSNLIVK | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. |
Sequence Annotation | REPEAT 286 335 Hemopexin 1.
REPEAT 336 382 Hemopexin 2.
REPEAT 384 432 Hemopexin 3.
REPEAT 433 476 Hemopexin 4.
MOTIF 89 96 Cysteine switch (By similarity).
ACT_SITE 218 218
METAL 91 91 Zinc; in inhibited form (By similarity).
METAL 167 167 Zinc 1.
METAL 169 169 Zinc 1.
METAL 182 182 Zinc 1.
METAL 195 195 Zinc 1.
METAL 217 217 Zinc 2; catalytic.
METAL 221 221 Zinc 2; catalytic.
METAL 227 227 Zinc 2; catalytic.
DISULFID 289 476 By similarity. |
Keyword | 3D-structure; Calcium; Collagen degradation; Complete proteome; Disulfide bond; Extracellular matrix; Hydrolase; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Signal; Zinc; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MMHLAFLVLL CLPVCSAYPL SGAAKEEDSN KDLAQQYLEK YYNLEKDVKQ FRRKDSNLIV 60
KKIQGMQKFL GLEVTGKLDT DTLEVMRKPR CGVPDVGHFS SFPGMPKWRK THLTYRIVNY 120
TPDLPRDAVD SAIEKALKVW EEVTPLTFSR LYEGEADIMI SFAVKEHGDF YSFDGPGHSL 180
AHAYPPGPGL YGDIHFDDDE KWTEDASGTN LFLVAAHELG HSLGLFHSAN TEALMYPLYN 240
SFTELAQFRL SQDDVNGIQS LYGPPPASTE EPLVPTKSVP SGSEMPAKCD PALSFDAIST 300
LRGEYLFFKD RYFWRRSHWN PEPEFHLISA FWPSLPSYLD AAYEVNSRDT VFIFKGNEFW 360
AIRGNEVQAG YPRGIHTLGF PPTIRKIDAA VSDKEKKKTY FFAADKYWRF DENSQSMEQG 420
FPRLIADDFP GVEPKVDAVL QAFGFFYFFS GSSQFEFDPN ARMVTHILKS NSWLHC 476 |
Gene Ontology | GO:0005615; C:extracellular space; TAS:ProtInc. GO:0005578; C:proteinaceous extracellular matrix; TAS:ProtInc. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004222; F:metalloendopeptidase activity; TAS:ProtInc. GO:0008270; F:zinc ion binding; TAS:ProtInc. GO:0030574; P:collagen catabolic process; TAS:Reactome. GO:0022617; P:extracellular matrix disassembly; TAS:Reactome. GO:0006508; P:proteolysis; TAS:ProtInc. GO:0030334; P:regulation of cell migration; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |