CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003818
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2D26 
Protein Synonyms/Alias
 CYPIID26; Cytochrome P450-CMF2; Cytochrome P450-DB2; Debrisoquine 4-hydroxylase 
Gene Name
 Cyp2d26 
Gene Synonyms/Alias
 Cyp2d-26; Cyp2d2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
210PFFNRMLKTLKESFGacetylation[1]
386HMTSRDIKFQGFLIPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 446 446 Iron (heme axial ligand).
 MOD_RES 138 138 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MGLLIGDDLW AVVIFTAIFL LLVDLVHRHK FWTAHYPPGP VPLPGLGNLL QVDFENMPYS 60
LYKLRSRYGD VFSLQIAWKP VVVINGLKAV RELLVTYGED TADRPLLPIY NHLGYGNKSK 120
GVVLAPYGPE WREQRRFSVS TLRDFGVGKK SLEQWVTEEA GHLCDTFAKE AEHPFNPSIL 180
LSKAVSNVIA SLVYARRFEY EDPFFNRMLK TLKESFGEDT GFMAEVLNAI PILLQIPGLP 240
GKVFPKLNSF IALVDKMLIE HKKSWDPAQP PRDMTDAFLA EMQKAKGNPE SSFNDENLRL 300
VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHEEIDE VIGQVRRPEM ADQARMPFTN 360
AVIHEVQRFA DIVPTNIPHM TSRDIKFQGF LIPKGTTLIP NLSSVLKDET VWEKPLRFHP 420
EHFLDAQGNF VKHEAFMPFS AGRRACLGEP LARMELFLFF TCLLQRFSFS VLAGRPRPST 480
HGVYALPVTP QPYQLCAVAR 500 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IDA:RGD.
 GO:0007565; P:female pregnancy; IEP:RGD.
 GO:0042493; P:response to drug; IDA:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.