CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030610
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centromere protein H 
Protein Synonyms/Alias
 Centromere protein H, isoform CRA_b; cDNA FLJ41767 fis, clone IMR322006495, highly similar to Centromere protein H (Kinetochore protein CENP-H) 
Gene Name
 CENPH 
Gene Synonyms/Alias
 hCG_27171 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51LRLRAQTKQQLLEYKubiquitination[1, 2]
76PEQIMQEKQIEAKIEubiquitination[1, 2, 3, 4]
81QEKQIEAKIEDLENEubiquitination[1]
119KHLLELNKLIMKSQQubiquitination[1]
123ELNKLIMKSQQESWDubiquitination[1]
146RKKRLQLKQASESKLubiquitination[1]
152LKQASESKLLEIQTEubiquitination[1]
160LLEIQTEKNKQKIDLubiquitination[1, 5]
162EIQTEKNKQKIDLDSubiquitination[1]
164QTEKNKQKIDLDSMEubiquitination[1]
215WAEDPALKEIVLQLEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 228 AA 
Protein Sequence
MEEQPQMQDA DEPADSGGEG RAGGPPQVAG AQAACSEDRM TLLLRLRAQT KQQLLEYKSM 60
VDASEEKTPE QIMQEKQIEA KIEDLENEIE EVKVAFEIKK LALDSVLMDN MKHLLELNKL 120
IMKSQQESWD LEEKLLDIRK KRLQLKQASE SKLLEIQTEK NKQKIDLDSM ENSERIKIIR 180
QNLQMEIKIT TVIQHVFQNL ILGSKVNWAE DPALKEIVLQ LEKNVDMM 228 
Gene Ontology
 GO:0000777; C:condensed chromosome kinetochore; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0043515; F:kinetochore binding; IEA:InterPro.
 GO:0051301; P:cell division; IEA:InterPro.
 GO:0007059; P:chromosome segregation; IEA:InterPro. 
Interpro
 IPR008426; Centromere_CenpH. 
Pfam
 PF05837; CENP-H 
SMART
  
PROSITE
  
PRINTS