CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031776
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PHD-finger domain-containing protein 
Protein Synonyms/Alias
  
Gene Name
 TGME49_024260 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
3651VAGEGEGKERSRQSPacetylation[1]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907
Functional Description
  
Sequence Annotation
  
Keyword
 Hydrolase; Metal-binding; Methyltransferase; Nucleotidyltransferase; Oxidoreductase; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5306 AA 
Protein Sequence
MAGGSMQRAA RQSRGRSGGR AGGGGGEGAS GSLGDRGCSD TEEERFWIEK DVEFFSAINP 60
RLLALLHHHK QSSEAFLSAV LPYLRSRSRK DAADAAGPSP RSEAAQAFAL RVPVRDFLRQ 120
DWTGGEIGGS VLSGSSAEER RDRRREEIIE RDSDPPKRVA SSPPCRSRSV EENLTERAAF 180
SRDGRSICSK DPQGAREEVS PSCDSLSSPV RRSSSASCLG ISQPVSSEAG SEAGSSSVFA 240
SGATAVAAGF ARTVPTSSGK GAASEGGENS PRSEGGNSVS SRVCSSQGSA PAPVVGCQAH 300
PAPSRLSQVW PHHTGKILLE RPSYSGETGR IIRHMWPATL LADVEPSALC PPPLLRSKKA 360
AADPKKKEDS RAYVRTGVEK KNLEESSRLS CGTEETEARG ESQKRSPDGG RSSQPHSSSV 420
SADLKETNRE TAESQADGSK TDAGLGLCSP WSEETGKTEE EKKDFESQPC GDAGGGRKDG 480
EEDRGGEETP QRSSGAVKEE TNASGEGRLP SGPQSPSKHL DQPGSAAWES SNPRILNGET 540
GSRDGEDSSS SCPEVGTQGP RPTSRRSSVE GRERRSAGLR AASDDKTEKS EDSREKEKDL 600
GAPQPSKDSQ EGQAASVEAT LQNTRTGAPS RAVPTTVLSG VKRELEQDGD TQGPRCGARS 660
PCRASATSPR DEPMSRPAGQ TSSEKWKREE AFCLQVSQNR SIFSLVPGAN DPALLASLHE 720
HQLHAHLKYQ SRDLSVFSHS GDFKRRAASA RGVSRRSGGR RGTRLAAGFD CEETAEGDFS 780
SGSLASSTPS SPAARAAGAR ERERNRRGSD SDFTPSRSEK GDARGDRPAA ARRRDGVSGT 840
VHQKAGSGSP GPSRAGREEV RAGGRTPSGE REPAQRSSSV GREAKAVVEG GEEDPDEAGA 900
DDLFVPTVHK KWNGSMRLPA FPTCRPPDAF VLSMFVPPNV SPADFPEDTN AQGDVSAFLA 960
VVMEAATTTA SDWDAHANTF TPHDGYNLAE KPGDCGPVRA LGKVAAERLG AERNRGTEGL 1020
GLVSREACRG HLLTTAGSCD MQETSRVGSG DSVAQVEAER RAQLERSFAC EGSEARPGHA 1080
RPVATEHPSA SHRRDLSKDG GLVKTPGGGR RRRRSSSTGS GGERTNSGNR RRLKDEKKRS 1140
SGTGAPVSPQ PRSSSGRFMS RQSLTEVSPA APTSSKPRAS VSPSSSLALV SASPRKRPRR 1200
RLPLPTVLSG PLPAWIDCSE RFPGPAPIVH GPRGPSGPFN AGLSFSASHG SCGGQASGLG 1260
MPGPCWGRPV WPETGAPFHI SGDEDPGRAG MNGKRALDKG SETRGGKASD EKREQSQAES 1320
EARLPSSSTT NASPPKHDPP CSSSPPPAER TGPRLEAEGM RSSHALFPPG QSYGGLSPGT 1380
QASGCSPSPG ALFSRASPAG PSSPGSTSSG VHPSQSFASP PSSCPPFAFS GTGPAAPYLA 1440
SGCHPCSFSV RPPACGAAAA FSPASPYAPC RPCAYLPQDA SSGPPPQISG SAYPGAALLS 1500
PPSSAPPGPV CAGPVSEAFS SMRHSFPAAC CPPHPCPPFS SCPPGHPQFC APGNPFSSYP 1560
SEMSPFPELQ RFSSAPPPPC TSFNCPPPYP PPACFPPAPE SSSSSVSSAD FVASFSSSPG 1620
PCRRASSAFS GSTSSEKSEE PPGVSSCQNL GSDATHPPCF SGPTYPVLGG PVDTAFCRPP 1680
PSTAPPGSVP FAAFPPFPCP PLLGLGPVAE FEDRGPVLRS FPFGPASSPA YLTLSLFPRP 1740
SLPAFPGSSA PFEPVSRCSS FLPRGELQTV SSSPPESVAS CLPTPPPEIL VPPFFGAGSS 1800
LKPFPPPCCL YPPEMAENFR YSEKRKMMVP SGVRLELLRA QMTRVDGLHT FYANVETGKR 1860
FFGERSFFEI AKENARRHDA GLQPLSLSPL TSNSATAFFM SVAPETEIPP SGSPNGPHTA 1920
PKKTKATKED SEREEREKRE REEREKRERD EERGRRDLEE KIRIHMYSRH MVPAGSPHLS 1980
GAHRLIPLPW GKRDASRSSP QELEIRARDG DCLHASTGAS AGVGGPQEKK GKTEDAQGEQ 2040
LVSLETAAEP ETQEKKETKA RGVAGVGPSA QSAETASPAP EAACDGQSAE VSPRGDSAAG 2100
RAETGPACGV TGERREVDRE SAQDEGKETE VKTEGPEGAC ETEEFTGCVS VEEGEGCGVK 2160
EITEKAKEGC ASDTANGGTR RELSEKEPGR DKDRVGMHTP FSSEGGEKEN REENGDDRES 2220
ADPFSLKEFN KHRQTSKPVG DVAEPDRVRE ENACPREQAE SEAMDVDGPE ARGELPEGRK 2280
DFEVLSSRNA TETADFDTRQ NEKQKAKGTL VTSTSFGTEV ENLLWRFSAL MDEKRAMCSR 2340
LLMSIEREKR PDWRAWAEVE DRMLRHYIEQ SAKSSLDTRH TYTLTQQSRD ILRLRVSCSS 2400
SGRLPPEWAE RALCTVCGSG EDWDEDPIMF CDGCYQPVHF LCLGHKAVSS YEEFVKASTT 2460
RRQRRVAQAG GDQGLAPATA RERGSGPKRD KKKAAERAKE EKKKGRGGTG DLLASGAFGA 2520
PALGAGSGDA PGASRPAEGD PSGPGASPGD TGHNTRRPVC GAGGFAFRED EEEWLCPVCE 2580
WLRKQLPQLD DELALAAIRL AAGPRSHSEA AECRGSYVGW HFERLEHFDS WVKPQLLALQ 2640
YGDGRRRKGK GRLQVDVGAP QGSRKDTRQG RKVATGLGLP SGDADSVSTL QAHSAYSVQE 2700
LLAWPAVRVV ADAGCLGPNA QSSRSSTSRG SAARGPGTAG ETGGVAGSGG DGSGVFRAEK 2760
DEEDRGLKKP ELDESGGRPS IRGAGPKPCI SSLAQTMLGA RTLPVWATDE ETGKQSCSRE 2820
GSVAGSKGGR LAADGRRLGG GERAGDRCVE PEEDDARRAK GDGDFSRDAW TRGFRSGSET 2880
GMGTSGKGAR EKHPVSLVAP EDATPATDYI RRVPYAFSDS SGDEGPSGKD GDTPFFFCQY 2940
TAGSPTASSP SSAAHRTPSQ EDDSQGGLFS GSAFSPSSAS MRSGAHASGG FSPNSAEPGA 3000
SLTSKHYCSK DPRRRCVVRV FPVPGLSVVL RVPVCALCGY DAFCRGGGPA RKTEKKGVWA 3060
HLRCALSLNA TVMDRVSYEA DESRSRLRCL FCHHQGPAPG HCGHAGCQRT YHVSCATATP 3120
GCMVDWDMGR PVIFCSQHAK NKAPTLILRK FQANREREAV KRREEDLPGE WKIGVGKGRL 3180
GIALQSLLFP SYDGLCNVFS DLLEVPTLRL PTLSPAEKKV TSQGLEALSF PGADPALGAP 3240
RDEAEALERR HRAQSREEKA TGVDEQRRGN AQTEDAAHRE KEEKGRNLEG SSVARGEAES 3300
GGGPDEEEER FTRRLTWRRR RVADSDAEDL EGKETKKKCP EEKAAGRTAE GADASVETSR 3360
DCGMEGESAS TAHAKQEVLD AGELRRETEG DSSPPSHSPK NVMVGEGVDN SRFPRASLEE 3420
QEWKKEKAEE KERRNWEKPE VIQSGLPSGE REEVCQSVGA AASREQGLSG SHAAHKEPQK 3480
EAEVSCLSST RDMTRVREAR EEPTFENRGK NDQTKPAEAE DRGNVRVDEF RLSRSPENES 3540
RLLSSLQKDR DEDKIEESEN RLAGARGTGE LRSDPTSASS SSAVNTVAGA DPGREVENVV 3600
AENCSSPSSF PGGQDDTLSF VLQERERSEA AAVLGKSESA TDAVAGEGEG KERSRQSPNG 3660
CGAGEETRDD ESRLDRQSGS TTDAPPLFLP SGSSDLLSLP PSLRLGETAG RCLPNGPAPP 3720
GEGVSEPVSS RVGSVLEGGT GARRGECVSH SQAGTSREQG GVSRGESDTA TPFSSGGETG 3780
ASHADEKPQR GPHSSLNFFA ALDLEGGRTQ NAAPGHKGTL ASPTGVAAPF GDPLENSPQN 3840
LFEANTSKSP FSPDGWGEAA FFSSASSFRS FSFTSGNPPG SSSEPAAPPR KRRGRPPLSR 3900
RSQGATHKDA VHRQDRDRVS SYLKMAAGGA LSRGGRFSLG GSCDRDKRRS LHLGGGRGSG 3960
MNLPERGPGG RFLPRGHREK NAQQTPVSDS VSTSSYQKQR PVSLSDPSQE GSADRRDGGD 4020
SGGENESQEN RELQAREEAL HQQRMRYMQM LFHLQALTRE RHRRLLGNDF ALTGLLLGSP 4080
DPAGAFDPGA LHAAGLPPTP LHGSSPATFF ARRVARLLDS PAPLAIRRSS TNGSAGTAGE 4140
EKVRGAPGGV GQADTATVET GVEEGPSGRA GAERGTGGAQ EENDEKEEKK ESVSGVSSCA 4200
ADANPDAGNR AKEARTKEAS ACVALASFSS PVDYLRLTTI KDWGLPQHTG DEKLFKCAFE 4260
ETKAANVLGI ETYDRFLARQ GVQSVARLLD AVVDLLLFFI LRGVCCAGPS PALLAALSEG 4320
KSLPQSRVPG GFVFPLALQL AGGSPAGGQK AKRAEGPGGS ERLCEAEEET EDSQREGKTP 4380
SAPLASSEEE PLYALIDTVR QLGQVAELDF KTGTDAIQKE EGAKKQLAVK REEPSVGTDD 4440
DEDEDELDEM KKRRSRTKQE KNAIATRRRQ TSAERDREQE MQERLREEDE TDWTCLRCAA 4500
VLNVGTPFPS TRCILCSRID GLLVRRIPED TPSLSNKKSG AFHVSCARQL GCRMETQRRS 4560
LDQQIHRAYC LEHTTQMNRK LLQQRLASHK PFAFPQRKDT LDLNRFFDPL QLLIADPIRS 4620
ITSLFLVGIH LERLAPPSLT SFAAFMRPSS LRLSSAEGGK QGEKEKRCRE AFGARGALHT 4680
SGRVDEQRAR YLKTGTHRPE ETGSVSWNAF DENDAFFEAV RERKKQRHGR REEGVGDRTR 4740
TGASAWSEGE REGRRERGLE SGDDYAASSA CDPLLTPGPP SPLHLEEQRE LYCTGVAICD 4800
ALYTQSRAFE EEALNLPSPS RSEVDAARAL YCVSEPASPD LRDRQRWTSA FEVTDGLMDD 4860
ENEKTTAGRT SSGSTSLERG RGVAWESGSK RRRVSLSSGS GGPPYFSGDA LSSVKDRVPP 4920
SCLTRSGLRS SLVSAAHASH FFDAGEDRGN QLVTPLESQK RVIDPARLTW SPQESVRRPS 4980
FVARAGLDGA VCLHDGGEAL PAPALTLSAE DSEAPTEEKR QSRDTGKALK FTQDAGNESS 5040
EKESRFSPDQ SLPHSDAESS GANAWGVSPS PALPSDGDSS GPRATASQTV SAVSCDSESI 5100
VLPPYLLRGT AVDLPSLTED VSPAASASAV LASESWYRGI SAAASMAVAH AVQAVSSRGD 5160
LDADEAEGAA REREEKQNGE SFDVLANLHI GSPGQVQGEK QPIFCPICKG MYNELPDGGP 5220
GDGFAWVGCD CCERWYHWTC SGFNEENPPP DDCDWICWFC TVKIRKKEEQ ERERQAHGLQ 5280
VKDKHRSGIK HSRSRPPPRK RDRSKR 5306 
Gene Ontology
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0004720; F:protein-lysine 6-oxidase activity; IEA:EC.
 GO:0003968; F:RNA-directed RNA polymerase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0034968; P:histone lysine methylation; IEA:GOC. 
Interpro
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
 SM00249; PHD
 SM00184; RING 
PROSITE
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS