CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038432
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tropomyosin alpha-1 chain 
Protein Synonyms/Alias
  
Gene Name
 Tpm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
212FAERSVTKLEKSIDDacetylation[1]
215RSVTKLEKSIDDLEDacetylation[1]
215RSVTKLEKSIDDLEDubiquitination[2]
228EDELYAQKLKYKAISacetylation[1]
228EDELYAQKLKYKAISubiquitination[2]
230ELYAQKLKYKAISEEacetylation[1]
230ELYAQKLKYKAISEEubiquitination[2]
232YAQKLKYKAISEELDubiquitination[2]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 248 AA 
Protein Sequence
MAGSSSLEAV RRKIRSLQEQ ADAAEERAGS LQRELDQERK LRETAEADVA SLNRRIQLVE 60
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 120
DADRKYEEVA RKLVIIESDL ERAEERAELS EGQVRQLEEQ LRIMDQTLKA LMAAEDKYSQ 180
KEDKYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDELYAQKLK YKAISEELDH 240
ALNDMTSI 248 
Gene Ontology
 GO:0005862; C:muscle thin filament tropomyosin; TAS:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI. 
Interpro
 IPR000533; Tropomyosin. 
Pfam
 PF00261; Tropomyosin 
SMART
  
PROSITE
 PS00326; TROPOMYOSIN 
PRINTS
 PR00194; TROPOMYOSIN.