CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040326
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 60S ribosomal protein L7 
Protein Synonyms/Alias
  
Gene Name
 Rpl7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36GRREKKKKVATVPGTubiquitination[1]
45ATVPGTLKKKVPAGPubiquitination[1]
88LRKKFALKTLRKARRacetylation[2]
88LRKKFALKTLRKARRubiquitination[1]
107EKAKHYHKEYRQMYRacetylation[3, 4]
125RMARMARKAGNFYVPubiquitination[1]
136FYVPAEPKLAFVIRIubiquitination[1]
155GVSPKVRKVLQLLRLacetylation[2, 5, 6]
155GVSPKVRKVLQLLRLsuccinylation[6]
172IFNGTFVKLNKASINacetylation[2]
172IFNGTFVKLNKASINubiquitination[1]
175GTFVKLNKASINMLRacetylation[6]
175GTFVKLNKASINMLRsuccinylation[6]
204SVNELIYKRGYGKINacetylation[2]
209IYKRGYGKINKKRIAacetylation[6]
209IYKRGYGKINKKRIAsuccinylation[6]
229LIARSLGKFGIICMEacetylation[2]
250YTVGKRFKEANNFLWacetylation[2]
260NNFLWPFKLSSPRGGacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 279 AA 
Protein Sequence
XEGVRGASAR RPWQYQEQTE GRLRIRLLGR REKKKKVATV PGTLKKKVPA GPKTLKKKVP 60
AVPETLKKKR RNFAELKVKR LRKKFALKTL RKARRKLIYE KAKHYHKEYR QMYRTEIRMA 120
RMARKAGNFY VPAEPKLAFV IRIRGINGVS PKVRKVLQLL RLRQIFNGTF VKLNKASINM 180
LRIVEPYIAW GYPNLKSVNE LIYKRGYGKI NKKRIALTDN SLIARSLGKF GIICMEDLIH 240
EIYTVGKRFK EANNFLWPFK LSSPRGGMKK KTTHFVEGG 279 
Gene Ontology
 GO:0022625; C:cytosolic large ribosomal subunit; IDA:MGI.
 GO:0003677; F:DNA binding; ISO:MGI.
 GO:0003729; F:mRNA binding; ISO:MGI.
 GO:0042803; F:protein homodimerization activity; ISO:MGI.
 GO:0003735; F:structural constituent of ribosome; IC:MGI.
 GO:0006412; P:translation; IC:MGI. 
Interpro
 IPR018038; Ribosomal_L30_CS.
 IPR016082; Ribosomal_L30_ferredoxin-like.
 IPR012988; Ribosomal_L30_N.
 IPR005998; Ribosomal_L7_euk. 
Pfam
 PF00327; Ribosomal_L30
 PF08079; Ribosomal_L30_N 
SMART
  
PROSITE
 PS00634; RIBOSOMAL_L30 
PRINTS