CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycine hydroxymethyltransferase, putative 
Protein Synonyms/Alias
  
Gene Name
 TGVEG_063010 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
564GKKLVDFKKGVPGNPacetylation[1, 2]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907]
 [2] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842] 
Functional Description
 Interconversion of serine and glycine (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; One-carbon metabolism; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 595 AA 
Protein Sequence
MDAFGPFYAP KFLRRCLLSR RKKPSLYKTR RLPVSVRATT CLHHRLFSFL ASEYSVVNSI 60
VPGSDAGFAC QASSKILSLP GRPIAYFTSS SYPFKMAPQS VPPVGNFSGL AAAVGTDHEE 120
ADVTMLQSAT PRGEAPKHGE EGSRPTGTKP LQALATQDPE LYELLREEKR RQISGLELIA 180
SENFTSQAVM ECLGSCLTNK YSEGYPGARY YGGNEVIDRI ECLCQRRALA AFGLDIEEWA 240
VNVQPYSGSP ANMAVFVGLL QPHDRIMGLD LPSGGHLTHG FYTAKKRISA TSIFFESLPY 300
GVDETTGLID YEELRKRALV FRPKLIICGH SAYPRDLDYV KFREIADAAG AMLMCDMAHT 360
SGLIAANLLT SPFPYCDIVT TTTHKTLRGP RSGMIFINKR RVPDGEGLIN SGVFPSLQGG 420
PHNHQIAALA CQLKEVMSPS WATYASQVIR NSKALAARLQ HHGHRLTTDG TDNHLLLMDL 480
RPDGITGTKM QLCCDEASIT LNKNTVPGDT SAANPSGVRI GSPALTTRGF KEKDFEQIAD 540
WLHEIVLIAQ EIQTNYGKKL VDFKKGVPGN PRLLEIKQAI TDWACSFSMP GQADI 595 
Gene Ontology
 GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006544; P:glycine metabolic process; IEA:InterPro.
 GO:0006563; P:L-serine metabolic process; IEA:InterPro.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 
Interpro
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase.
 IPR019798; Ser_HO-MeTrfase_PLP_BS. 
Pfam
 PF00464; SHMT 
SMART
  
PROSITE
 PS00096; SHMT 
PRINTS