| Tag | Content |
|---|
| CPLM ID | CPLM-024427 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Homeodomain-interacting protein kinase 1 |
Protein Synonyms/Alias | |
Gene Name | Hipk1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 421 | YLLSAGTKTTRFFNR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation (By similarity). |
Sequence Annotation | DOMAIN 190 518 Protein kinase.
NP_BIND 196 204 ATP (By similarity).
REGION 844 847 Nuclear localization signal 1 (NLS1) (By
REGION 885 1094 Interaction with TP53 (By similarity).
REGION 891 998 Required for localization to nuclear
REGION 902 926 SUMO interaction motifs (SIM); required
ACT_SITE 315 315 Proton acceptor (By similarity).
BINDING 219 219 ATP (By similarity).
MOD_RES 352 352 Phosphotyrosine (By similarity).
MOD_RES 872 872 Phosphoserine (By similarity).
CROSSLNK 25 25 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 1204 1204 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1211 AA |
Protein Sequence | MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP ATQGQASSSH 60
QVANFNIPAY DQGLLLQAPA VEHIVVTAAD SSGSAATATF QSSQTLTHRS NVSLLEPYQK 120
CGLKRKSEEV DSNGSVQIIE EHPPLMLQNR TVVGAAATTT TVTTKSSSSS GEGDYQLVQH 180
EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240
LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360
PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420
KTTRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480
MLAEKADRRE YIDLLKKMLT IDADKRVTPL KTLNHQFVTM THLLDFPHSN HVKSCFQNME 540
ICKRRVHMYD TVSQIKSPFT THVAPSTSTN LTMSFSNQLS TVHNQASVLA SSSTAAAATL 600
SLANSDVSLL NYQSALYPPS AAPVPGVAQQ GVSLQPGTTQ ICTQTDPFQQ TFIVCPPAFQ 660
TGLQATTKHS GFPVRMDNAV PLVPQAPAAQ PLQIQSGVLT QGSCTPLMVA TLHPQVATIT 720
PQYAVPFTLS CAAGRPALVE QTAAVQQAWP GGTQQILLPS AWQQLPGVAL HNSVQPTAVI 780
PEAMGSSQQL ADWRNAHSHG NQYSTIMQQP SLLTNHVTLA TAQPLNVGVA HVVRQQQSSS 840
LPSRKNKQSA PVSSTSSLEV LPSQVYSLVG SSPLRTTSSY NSLVPVQDQH QPIIIPDTPS 900
PPVSVITIRS DTDEEEDNKF KPSSSSLKAR SNVISYVTVN DSPDSDSSLS SPYPTDTLSA 960
LRGNSGTLLE GPGRTAADGI GTRTIIVPPL KTQLGDCTGA TQASGLLSSS KTKPVASVSG 1020
QSSGCCITPT GYRAQRGGAS AVQPLNLSQN QQSSSASTSQ ERSSNPAPRR QQAFVAPLSQ 1080
APYAFQHGSP LHSTGHPHLA PAPAHLPSQP HLYTYAAPTS AAALGSTSSI AHLFSPQGSS 1140
RHAAAYTTHP STLVHQVPVS VGPSLLTSAS VAPAQYQHQF ATQSYIGSSR GSTIYTGYPL 1200
SPTKISQYSY L 1211 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |