UniProt Accession

 RPP38_HUMAN; P78345; B3KPY0; D3DRT8; Q53F71; Q8NHS8 

Genbank Protein ID

 U77664; AK057006; CR541816; AK223418; AL590365; CH471072; CH471072; BC029494 

Genbank Nucleotide ID

 AAC51142.1; BAG51842.1; CAG46615.1; BAD97138.1; CAH73968.1; EAW86240.1; EAW86241.1; AAH29494.1 

Protein Name

 Ribonuclease P protein subunit p38 

Protein Synonyms/Alias

 RNaseP protein p38 

Gene Name

 RPP38 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	QTLEDRLKAIGLQKI	ubiquitination	[1]
59	LKAIGLQKIEDKKKK	ubiquitination	[2]
111	WTPAHVRKQLAIGVN	ubiquitination	[1]
241	TSFEDLSKPKRKLAD	acetylation	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 226 226 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005655; C:nucleolar ribonuclease P complex; TAS:ProtInc.
 GO:0004526; F:ribonuclease P activity; TAS:ProtInc.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45. 

Pfam

 PF01248; Ribosomal_L7Ae 

SMART

  

PROSITE

  

PRINTS