UniProt Accession

 HSFA2_ARATH; O80982 

Genbank Protein ID

 AC004747; CP002685; AK118744 

Genbank Nucleotide ID

 AAC31222.1; AEC07800.1; BAC43337.1 

Protein Name

 Heat stress transcription factor A-2 

Protein Synonyms/Alias

 AtHsfA2; AtHsf-04 

Gene Name

 HSFA2 

Gene Synonyms/Alias

 HSF04; At2g26150; T19L18.4 

Created Date

 July 27, 2013 

Organism

 Arabidopsis thaliana (Mouse-ear cress) 

NCBI Taxa ID

 3702 

Lysine Modification

Position	Peptide	Type	References
167	DGEVERLKRDHGVLV	sumoylation	[1]
315	LEAALDVKVEDLVGS	sumoylation	[1]

Reference

 [1] Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modifies its activity during acquired thermotholerance.
 Cohen-Peer R, Schuster S, Meiri D, Breiman A, Avni A.
 Plant Mol Biol. 2010 Sep;74(1-2):33-45. [PMID: 20521085] 

Functional Description

 Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). 

Sequence Annotation

 DNA_BIND 42 136 By similarity.
 REGION 150 216 Hydrophobic repeat HR-A/B.
 MOTIF 230 245 Bipartite nuclear localization signal
 MOTIF 273 282 AHA1.
 MOTIF 324 333 AHA2.
 MOTIF 334 341 Nuclear export signal (Potential).
 CROSSLNK 315 315 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Stress response; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:TAIR.
 GO:0034605; P:cellular response to heat; IEP:TAIR.
 GO:0071456; P:cellular response to hypoxia; IEP:TAIR.
 GO:0034620; P:cellular response to unfolded protein; IEP:TAIR.
 GO:0010286; P:heat acclimation; IMP:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0010200; P:response to chitin; IEP:TAIR.
 GO:0009644; P:response to high light intensity; IEP:TAIR.
 GO:0042542; P:response to hydrogen peroxide; IEP:TAIR.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000232; HSF_DNA-bd.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00447; HSF_DNA-bind 

SMART

 SM00415; HSF 

PROSITE

 PS00434; HSF_DOMAIN 

PRINTS

 PR00056; HSFDOMAIN.