CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030744
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein DEK 
Protein Synonyms/Alias
 cDNA FLJ53031, highly similar to Protein DEK 
Gene Name
 DEK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21PTQPASEKEPEMPGPacetylation[1]
57KSLIVEGKREKKKVEubiquitination[2]
83DELRNLHKLLYNRPGubiquitination[3]
97GTVSSLKKNVGQFSGubiquitination[3]
109FSGFPFEKGSVQYKKubiquitination[3]
149GVNSELVKRILNFLMubiquitination[2, 4]
303ELKETIKKLLASANLubiquitination[3]
321TMKQICKKVYENYPTubiquitination[1, 3]
343DFIKTTVKELIS***ubiquitination[2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 347 AA 
Protein Sequence
MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK SLIVEGKREK 60
KKVERIHFFL SKKKTDELRN LHKLLYNRPG TVSSLKKNVG QFSGFPFEKG SVQYKKKEEM 120
LKKFRNAMLK SICEVLDLER SGVNSELVKR ILNFLMHPKP SGKPLPKSKK TCSKGSKKER 180
NSSGMARKAK RTKCPEILSD ESSSDEDEKK NKEESSDDED KESEEEPPKK TAKREKPKQK 240
ATSKSKKSVK SANVKKADSS TTKKNQNSSK KESESEDSSD DEPLIKKLKK PPTDEELKET 300
IKKLLASANL EEVTMKQICK KVYENYPTYD LTERKDFIKT TVKELIS 347 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro. 
Interpro
 IPR014876; DEK_C.
 IPR009057; Homeodomain-like.
 IPR003034; SAP_dom. 
Pfam
 PF08766; DEK_C
 PF02037; SAP 
SMART
 SM00513; SAP 
PROSITE
  
PRINTS