CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024544
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TANK-binding kinase 1-binding protein 1 
Protein Synonyms/Alias
 TBK1-binding protein 1 
Gene Name
 TBKBP1 
Gene Synonyms/Alias
 KIAA0775 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
94GFSLYEIKDGSLLEVubiquitination[1]
119QFQHELQKNKEQEEQubiquitination[1]
121QHELQKNKEQEEQLGubiquitination[2]
262ERLQGELKQLQETRAubiquitination[1]
285ERDMAWVKRVGDDQVubiquitination[2]
614DSHLENSKI******ubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity (By similarity). 
Sequence Annotation
 MOD_RES 184 184 Phosphoserine.
 MOD_RES 365 365 Phosphoserine.
 MOD_RES 372 372 Phosphoserine.
 MOD_RES 379 379 Phosphoserine.
 MOD_RES 385 385 Phosphoserine.
 MOD_RES 400 400 Phosphoserine.
 MOD_RES 415 415 Phosphoserine.
 MOD_RES 504 504 Phosphoserine.
 MOD_RES 534 534 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Immunity; Innate immunity; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 615 AA 
Protein Sequence
MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD IKERLGGLER 60
ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE VEKVSLQQRL NQFQHELQKN 120
KEQEEQLGEM IQAYEKLCVE KSDLETELRE MRALVETHLR QICGLEQQLR QQQGLQDAAF 180
SNLSPPPAPA PPCTDLDLHY LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA 240
RGAQLREEQL QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE 300
LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP SPPARAAPPC 360
PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS PVPPSCQSPS PQRRSPVPPS 420
CPAPQPRPPP PPPPGERTLA ERAYAKPPSH HVKAGFQGRR SYSELAEGAA YAGASPPWLQ 480
AEAATLPKPR AYGSELYGPG RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI 540
RCASFCAGFP IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD 600
ALIKHIDSHL ENSKI 615 
Gene Ontology
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW. 
Interpro
 IPR024581; TBD. 
Pfam
 PF12845; TBD 
SMART
  
PROSITE
  
PRINTS