| Tag | Content |
|---|
| CPLM ID | CPLM-002037 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcriptional activator protein LysR |
Protein Synonyms/Alias | |
Gene Name | lysR |
Gene Synonyms/Alias | b2839; JW2807 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 44 | RELARFEKVIGLKLF | acetylation | [1] | | 49 | FEKVIGLKLFERVRG | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression. |
Sequence Annotation | DOMAIN 1 61 HTH lysR-type.
DNA_BIND 21 40 H-T-H motif (By similarity). |
Keyword | Activator; Complete proteome; Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 311 AA |
Protein Sequence | MAAVNLRHIE IFHAVMTAGS LTEAAHLLHT SQPTVSRELA RFEKVIGLKL FERVRGRLHP 60
TVQGLRLFEE VQRSWYGLDR IVSAAESLRE FRQGELSIAC LPVFSQSFLP QLLQPFLARY 120
PDVSLNIVPQ ESPLLEEWLS AQRHDLGLTE TLHTPAGTER TELLSLDEVC VLPPGHPLAV 180
KKVLTPDDFQ GENYISLSRT DSYRQLLDQL FTEHQVKRRM IVETHSAASV CAMVRAGVGI 240
SVVNPLTALD YAASGLVVRR FSIAVPFTVS LIRPLHRPSS ALVQAFSGHL QAGLPKLVTS 300
LDAILSSATT A 311 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0009089; P:lysine biosynthetic process via diaminopimelate; IDA:EcoCyc. GO:0010628; P:positive regulation of gene expression; IMP:EcoCyc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |