UniProt Accession

 AMZ2_HUMAN; Q86W34; A6NLD9; B3KR44; Q5XKF1; Q9NZE2 

Genbank Protein ID

 AJ635358; AF208856; AK126146; AK090981; AC005332; CH471099; BC050709; BC056271 

Genbank Nucleotide ID

 CAG25750.1; AAF64270.1; BAC86462.1; BAG52256.1; EAW89050.1; AAH50709.1; AAH56271.1 

Protein Name

 Archaemetzincin-2 

Protein Synonyms/Alias

 Archeobacterial metalloproteinase-like protein 2 

Gene Name

 AMZ2 

Gene Synonyms/Alias

 BM-014 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
28	VLVSQYEKLNAGEQR	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2. 

Sequence Annotation

 ACT_SITE 255 255 Proton acceptor (By similarity).
 METAL 254 254 Zinc 1; catalytic; via tele nitrogen (By
 METAL 258 258 Zinc 1; catalytic; via tele nitrogen (By
 METAL 264 264 Zinc 1; catalytic; via tele nitrogen (By
 METAL 265 265 Zinc 2 (By similarity).
 METAL 270 270 Zinc 2 (By similarity).
 METAL 289 289 Zinc 2 (By similarity).
 METAL 292 292 Zinc 2 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR024079; MetalloPept_cat_dom.
 IPR012962; Pept_M54_archaemetzincn. 

Pfam

 PF07998; Peptidase_M54 

SMART

  

PROSITE

 PS00142; ZINC_PROTEASE 

PRINTS