UniProt Accession

 T22D3_HUMAN; Q99576; Q5H9S3; Q5JRI9; Q6FIH6; Q8NAI1; Q8WVB9; Q9UBN5; Q9UG13 

Genbank Protein ID

 Z50781; AF228339; AF183393; AB025432; AF153603; AL110191; AK092645; AK092669; AL590423; CH471120; CH471120; CH471120; CR933650; BC018148; BC072446; CR533450 

Genbank Nucleotide ID

 CAA90644.1; AAG12456.1; AAD56234.1; BAB18680.1; AAD41085.1; CAB53669.1; BAC03934.1; BAG52587.1; CAI41544.1; EAX02704.1; EAX02705.1; EAX02706.1; CAI45951.1; AAH18148.3; AAH72446.1; CAG38481.1 

Protein Name

 TSC22 domain family protein 3 

Protein Synonyms/Alias

 DSIP-immunoreactive peptide; Protein DIP; hDIP; Delta sleep-inducing peptide immunoreactor; Glucocorticoid-induced leucine zipper protein; GILZ; TSC-22-like protein; TSC-22-related protein; TSC-22R 

Gene Name

 TSC22D3 

Gene Synonyms/Alias

 DSIPI; GILZ 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	SVVAIDNKIEQAMDL	ubiquitination	[1, 2]
62	EQAMDLVKNHLMYAV	ubiquitination	[1]
77	REEVEILKEQIRELV	ubiquitination	[1]
86	QIRELVEKNSQLERE	ubiquitination	[1]
98	ERENTLLKTLASPEQ	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). 

Sequence Annotation

 REGION 1 60 AP1-binding (By similarity).
 REGION 76 97 Leucine-zipper.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 134 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0007589; P:body fluid secretion; IEA:Compara.
 GO:0034220; P:ion transmembrane transport; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0048642; P:negative regulation of skeletal muscle tissue development; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006970; P:response to osmotic stress; IEA:Compara. 

Interpro

 IPR000580; TSC-22_Dip_Bun. 

Pfam

 PF01166; TSC22 

SMART

  

PROSITE

 PS01289; TSC22 

PRINTS