UniProt Accession

 TXNIP_RAT; Q5M7W1 

Genbank Protein ID

 BC088411 

Genbank Nucleotide ID

 AAH88411.1 

Protein Name

 Thioredoxin-interacting protein 

Protein Synonyms/Alias

 Vitamin D3 up-regulated protein 1 

Gene Name

 Txnip 

Gene Synonyms/Alias

 Vdup1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
26	KVYGSGEKVAGRVTV	ubiquitination	[1]
115	GPLGTSFKGKYGCVD	ubiquitination	[2]
117	LGTSFKGKYGCVDYW	ubiquitination	[2]
140	SQPTQEAKKNFEVMD	ubiquitination	[2]
163	LMAPVSAKKEKKVSC	ubiquitination	[2]
167	VSAKKEKKVSCMFIP	ubiquitination	[2]
187	VSARIDRKGFCEGDD	ubiquitination	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity). 

Sequence Annotation

 MOD_RES 361 361 Phosphoserine (By similarity).
 CROSSLNK 212 212 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Cell cycle; Complete proteome; Cytoplasm; Isopeptide bond; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 394 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0004857; F:enzyme inhibitor activity; IEA:Compara.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0071228; P:cellular response to tumor cell; ISS:UniProtKB.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0051782; P:negative regulation of cell division; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
 GO:0006606; P:protein import into nucleus; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IDA:RGD.
 GO:0051592; P:response to calcium ion; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0009612; P:response to mechanical stimulus; IEP:RGD.
 GO:0032570; P:response to progesterone stimulus; IEP:RGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011021; Arrestin-like_N.
 IPR011022; Arrestin_C-like.
 IPR014756; Ig_E-set. 

Pfam

 PF02752; Arrestin_C
 PF00339; Arrestin_N 

SMART

 SM01017; Arrestin_C 

PROSITE

  

PRINTS