UniProt Accession

 S22A5_HUMAN; O76082; A2Q0V1; B2R844; D3DQ87; Q6ZQZ8; Q96EH6 

Genbank Protein ID

 AF057164; AB015050; AB016625; AB291606; AK128610; AK313230; AC118464; CH471062; CH471062; BC012325 

Genbank Nucleotide ID

 AAC24828.1; BAA29023.1; BAA36712.1; BAF45812.1; BAC87527.1; BAG36041.1; EAW62337.1; EAW62338.1; AAH12325.1 

Protein Name

 Solute carrier family 22 member 5 

Protein Synonyms/Alias

 High-affinity sodium-dependent carnitine cotransporter; Organic cation/carnitine transporter 2 

Gene Name

 SLC22A5 

Gene Synonyms/Alias

 OCTN2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
302	VIIRKAAKANGIVVP	ubiquitination	[1]
324	ELQDLSSKKQQSHNI	ubiquitination	[1, 2]
543	PSHTRMLKDGQERPT	ubiquitination	[1]
553	QERPTILKSTAF***	ubiquitination	[1, 2, 3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. 

Sequence Annotation

 NP_BIND 218 225 ATP (Potential).
 MOD_RES 486 486 Phosphotyrosine.
 CARBOHYD 57 57 N-linked (GlcNAc...).
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 91 91 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Disease mutation; Glycoprotein; Ion transport; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 557 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:BHF-UCL.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0031526; C:brush border membrane; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042895; F:antibiotic transporter activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015226; F:carnitine transmembrane transporter activity; IDA:BHF-UCL.
 GO:0015238; F:drug transmembrane transporter activity; IC:BHF-UCL.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0060731; P:positive regulation of intestinal epithelial structure maintenance; IMP:BHF-UCL.
 GO:0052106; P:quorum sensing involved in interaction with host; IMP:BHF-UCL.
 GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
 GO:0070715; P:sodium-dependent organic cation transport; IDA:BHF-UCL. 

Interpro

 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR004749; Orgcat_transp.
 IPR005828; Sub_transporter.
 IPR005829; Sugar_transporter_CS. 

Pfam

 PF00083; Sugar_tr 

SMART

  

PROSITE

 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1 

PRINTS