UniProt Accession

 VANG2_RAT; P84889 

Genbank Protein ID

 AABR03084676 

Genbank Nucleotide ID

  

Protein Name

 Vang-like protein 2 

Protein Synonyms/Alias

 Van Gogh-like protein 2 

Gene Name

 Vangl2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
507	SEEFVDPKSHKFVMR	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Developmental protein; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 521 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0060187; C:cell pole; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0045176; P:apical protein localization; IEA:Compara.
 GO:0035787; P:cell migration involved in kidney development; IEA:Compara.
 GO:0090103; P:cochlea morphogenesis; IEA:Compara.
 GO:0060028; P:convergent extension involved in axis elongation; IEA:Compara.
 GO:0022007; P:convergent extension involved in neural plate elongation; IEA:Compara.
 GO:0048546; P:digestive tract morphogenesis; IEA:Compara.
 GO:0048105; P:establishment of body hair planar orientation; IEA:Compara.
 GO:0090177; P:establishment of planar polarity involved in neural tube closure; IEA:Compara.
 GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IEA:Compara.
 GO:0001942; P:hair follicle development; IEA:Compara.
 GO:0001947; P:heart looping; IEA:Compara.
 GO:0060122; P:inner ear receptor stereocilium organization; IEA:Compara.
 GO:0060490; P:lateral sprouting involved in lung morphogenesis; IEA:Compara.
 GO:0003149; P:membranous septum morphogenesis; IEA:Compara.
 GO:0003150; P:muscular septum morphogenesis; IEA:Compara.
 GO:0035058; P:nonmotile primary cilium assembly; IEA:Compara.
 GO:0060488; P:orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; IEA:Compara.
 GO:0003402; P:planar cell polarity pathway involved in axis elongation; IEA:Compara.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Compara.
 GO:0060489; P:planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; IEA:Compara.
 GO:0043507; P:positive regulation of JUN kinase activity; IEA:Compara.
 GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Compara.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara.
 GO:0048103; P:somatic stem cell division; IEA:Compara.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0042060; P:wound healing; IEA:Compara. 

Interpro

 IPR009539; Strabismus. 

Pfam

 PF06638; Strabismus 

SMART

  

PROSITE

  

PRINTS