UniProt Accession

 P5CR_YEAST; P32263; D3DLS2 

Genbank Protein ID

 M57886; X57338; U18778; BK006939 

Genbank Nucleotide ID

 AAA34905.1; CAA40614.1; AAB64556.1; DAA07676.1 

Protein Name

 Pyrroline-5-carboxylate reductase 

Protein Synonyms/Alias

 P5C reductase; P5CR 

Gene Name

 PRO3 

Gene Synonyms/Alias

 ORE2; YER023W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
140	VMTNTPAKYGYGCAV	ubiquitination	[1]
171	ELISQVGKYVELPEK	acetylation	[2]
171	ELISQVGKYVELPEK	ubiquitination	[1, 3]
216	GIPLQESKECAMKVL	ubiquitination	[1]
221	ESKECAMKVLEGTVK	ubiquitination	[1]
228	KVLEGTVKMVEKSGA	ubiquitination	[1]
232	GTVKMVEKSGAHPSV	acetylation	[2]
232	GTVKMVEKSGAHPSV	ubiquitination	[1]
264	VMEEKGVKSGIINGV	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

  

Sequence Annotation

 MOD_RES 246 246 Phosphothreonine.
 MOD_RES 279 279 Phosphoserine.  

Keyword

 Amino-acid biosynthesis; Complete proteome; NADP; Oxidoreductase; Phosphoprotein; Proline biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004735; F:pyrroline-5-carboxylate reductase activity; IGI:SGD.
 GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006561; P:proline biosynthetic process; IMP:SGD. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR004455; NADP_OxRdtase_F420.
 IPR000304; Pyrroline-COOH_reductase. 

Pfam

 PF03807; F420_oxidored 

SMART

  

PROSITE

 PS00521; P5CR 

PRINTS