| Tag | Content |
|---|
| CPLM ID | CPLM-002140 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial brown fat uncoupling protein 1 |
Protein Synonyms/Alias | UCP 1; Solute carrier family 25 member 7; Thermogenin |
Gene Name | Ucp1 |
Gene Synonyms/Alias | Slc25a7; Ucp |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 67 | GTITTLAKTEGLPKL | acetylation | [1] | | 73 | AKTEGLPKLYSGLPA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. |
Sequence Annotation | REPEAT 11 102 Solcar 1.
REPEAT 111 201 Solcar 2.
REPEAT 210 295 Solcar 3.
REGION 274 296 Purine nucleotide binding (By |
Keyword | Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 307 AA |
Protein Sequence | MVSSTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS STIRYKGVLG 60
TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDTVQ EYFSSGRETP ASLGSKISAG 120
LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI KPRYTGTYNA YRVIATTESL STLWKGTTPN 180
LMRNVIINCT ELVTYDLMKG ALVNHHILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF 240
INSLPGQYPS VPSCAMTMYT KEGPAAFFKG FAPSFLRLGS WNVIMFVCFE QLKKELMKSR 300
QTVDCTT 307 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; TAS:RGD. GO:0017077; F:oxidative phosphorylation uncoupler activity; IDA:RGD. GO:0032870; P:cellular response to hormone stimulus; IEP:RGD. GO:0006091; P:generation of precursor metabolites and energy; TAS:RGD. GO:0006839; P:mitochondrial transport; IDA:RGD. GO:0044253; P:positive regulation of multicellular organismal metabolic process; TAS:RGD. GO:0048545; P:response to steroid hormone stimulus; IEP:RGD. |
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