| Tag | Content |
|---|
| CPLM ID | CPLM-011798 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | U3 small nucleolar RNA-associated protein 12 |
Protein Synonyms/Alias | U3 snoRNA-associated protein 12; DOM34-interacting protein 2; U three protein 12 |
Gene Name | DIP2 |
Gene Synonyms/Alias | UTP12; YLR129W; L3116; L9233.1 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 237 | KLDIENDKMGGKLTE | acetylation | [1] | | 350 | WTTVSSSKLELVLTT | methylation | [2] | | 515 | LVPGTKNKFLPVLKL | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] [2] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications. Pang CN, Gasteiger E, Wilkins MR. BMC Genomics. 2010 Feb 5;11:92. [ PMID: 20137074] |
Functional Description | Involved in nucleolar processing of pre-18S ribosomal RNA. |
Sequence Annotation | REPEAT 77 107 WD 1.
REPEAT 119 149 WD 2.
REPEAT 161 190 WD 3.
REPEAT 202 230 WD 4.
REPEAT 389 418 WD 5.
REPEAT 428 458 WD 6.
REPEAT 471 501 WD 7.
REPEAT 571 601 WD 8.
REPEAT 613 643 WD 9.
REPEAT 655 685 WD 10. |
Keyword | Complete proteome; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; Ribosome biogenesis; rRNA processing; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 943 AA |
Protein Sequence | MVKSYQRFEQ AAAFGVIASN ANCVWIPASS GNSNGSGPGQ LITSALEDVN IWDIKTGDLV 60
SKLSDGLPPG ASDARGAKPA ECTYLEAHKD TDLLAVGYAD GVIKVWDLMS KTVLLNFNGH 120
KAAITLLQFD GTGTRLISGS KDSNIIVWDL VGEVGLYKLR SHKDSITGFW CQGEDWLIST 180
SKDGMIKLWD LKTHQCIETH IAHTGECWGL AVKDDLLITT GTDSQVKIWK LDIENDKMGG 240
KLTEMGIFEK QSKQRGLKIE FITNSSDKTS FFYIQNADKT IETFRIRKEE EIARGLKKRE 300
KRLKEKGLTE EEIAKSIKES YSSFILHPFQ TIRSLYKIKS ASWTTVSSSK LELVLTTSSN 360
TIEYYSIPYE KRDPTSPAPL KTHTIELQGQ RTDVRSIDIS DDNKLLATAS NGSLKIWNIK 420
THKCIRTFEC GYALTCKFLP GGLLVILGTR NGELQLFDLA SSSLLDTIED AHDAAIWSLD 480
LTSDGKRLVT GSADKTVKFW DFKVENSLVP GTKNKFLPVL KLHHDTTLEL TDDILCVRVS 540
PDDRYLAISL LDNTVKVFFL DSMKFYLSLY GHKLPVLSID ISFDSKMIIT SSADKNIKIW 600
GLDFGDCHKS LFAHQDSIMN VKFLPQSHNF FSCSKDAVVK YWDGEKFECI QKLYAHQSEV 660
WALAVATDGG FVVSSSHDHS IRIWEETEDQ VFLEEEKEKE LEEQYEDTLL TSLEEGNGDD 720
AFKADASGEG VEDEASGVHK QTLESLKAGE RLMEALDLGI AEIEGLEAYN RDMKLWQRKK 780
LGEAPIKPQG NAVLIAVNKT PEQYIMDTLL RIRMSQLEDA LMVMPFSYVL KFLKFIDTVM 840
QNKTLLHSHL PLICKNLFFI IKFNHKELVS QKNEELKLQI NRVKTELRSA LKSTEDDLGF 900
NVQGLKFVKQ QWNLRHNYEF VDEYDQQEKE SNSARKRVFG TVI 943 |
Gene Ontology | GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IDA:SGD. GO:0032040; C:small-subunit processome; IDA:SGD. GO:0030515; F:snoRNA binding; IPI:SGD. GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. |
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PROSITE | |
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