UniProt Accession

 PRDX5_MOUSE; P99029; Q9QX45; Q9QZ75 

Genbank Protein ID

 AF197951; AF124994; AF110733; AF208730; AF208729; AK002383; AK003332; BC008174 

Genbank Nucleotide ID

 AAF04855.1; AAF27532.1; AAG13450.1; AAF21016.1; AAF21016.1; BAB22058.1; BAB22720.1; AAH08174.1 

Protein Name

 Peroxiredoxin-5, mitochondrial 

Protein Synonyms/Alias

 Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 2D-0014IV; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; Thioredoxin peroxidase PMP20; Thioredoxin reductase 

Gene Name

 Prdx5 

Gene Synonyms/Alias

 Prdx6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	VFEGEPGKKVNLAEL	acetylation	[1]
31	VNLAELFKGKKGVLF	acetylation	[1]
64	VEQAGALKAKGAQVV	acetylation	[1]
94	RAHQAEGKVRLLADP	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling. 

Sequence Annotation

 DOMAIN 52 210 Thioredoxin.
 MOTIF 208 210 Microbody targeting signal (By
 ACT_SITE 96 96 Cysteine sulfenic acid (-SOH)
 MOD_RES 79 79 N6-acetyllysine (By similarity).
 DISULFID 96 200 Redox-active (By similarity).  

Keyword

 Acetylation; Alternative initiation; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Mitochondrion; Oxidoreductase; Peroxidase; Peroxisome; Redox-active center; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005782; C:peroxisomal matrix; ISS:UniProtKB.
 GO:0016209; F:antioxidant activity; ISS:UniProtKB.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Compara.
 GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
 GO:0072541; F:peroxynitrite reductase activity; IEA:Compara.
 GO:0005102; F:receptor binding; ISS:UniProtKB.
 GO:0001016; F:RNA polymerase III regulatory region DNA binding; IEA:Compara.
 GO:0042744; P:hydrogen peroxide catabolic process; ISS:UniProtKB.
 GO:0070995; P:NADPH oxidation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0051354; P:negative regulation of oxidoreductase activity; IEA:Compara.
 GO:0016480; P:negative regulation of transcription from RNA polymerase III promoter; IEA:Compara.
 GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Compara.
 GO:2001057; P:reactive nitrogen species metabolic process; IEA:Compara.
 GO:0060785; P:regulation of apoptosis involved in tissue homeostasis; IEA:Compara. 

Interpro

 IPR013740; Redoxin.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF08534; Redoxin 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS