CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036188
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sorting nexin-14 
Protein Synonyms/Alias
  
Gene Name
 SNX14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
246DELHYLRKLTELLFPubiquitination[1]
321PLVPFLQKFAEPRNKubiquitination[1, 2, 3]
338SVLKLELKQIREQQDubiquitination[1, 2, 4]
426IQRRKIIKSVPGKLMubiquitination[1]
475PTSENNKKLFNDLFKubiquitination[1, 5]
482KLFNDLFKNNANRAEubiquitination[1, 2, 3]
592QDKQKGAKQTFEEMMubiquitination[1, 2, 3]
656PELNKVQKEVTSVTSubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 665 AA 
Protein Sequence
MVPWVRTMGQ KLKQRLRLDV GREICRQYPL FCFLLLCLSA ASLLLNRYIH ILMIFWSFVA 60
GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGHS CAVCGKVKCK RHRPSLLLEN 120
YQPWLDLKIS SKVDASLSEV LELVLENFVY PWYRDVTDDE SFVDELRITL RFFASVLIRR 180
IHKVDIPSII TKKLLKAAMK HIEVIVKARQ KVKNTEFLQQ AALEEYGPEL HVALRSRRDE 240
LHYLRKLTEL LFPYILPPKA TDCRSLTLLI REILSGSVFL PSLDFLADPD TVNHLLIIFI 300
DDSPPEKATE PASPLVPFLQ KFAEPRNKKP SVLKLELKQI REQQDLLFRF MNFLKQEGAV 360
HVLQFCLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY CLDESIDKIR FDPFIVEEIQ 420
RRKIIKSVPG KLMKEKGQHL EPFIMNFINS CESPKPKPSR PELTILSPTS ENNKKLFNDL 480
FKNNANRAEN TERKQNQNYF MEVMTVEGVY DYLMYVGRVV FQVPDWLHHL LMGTRILFKN 540
TLEMYTDYYL QCKLEQLFQE HRLVSLITLL RDAIFCENTE PRSLQDKQKG AKQTFEEMMN 600
YIPDLLVKCI GEETKYESIR LLFDGLQQPV LNKQLTYVLL DIVIQELFPE LNKVQKEVTS 660
VTSWM 665 
Gene Ontology
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR003114; Phox_assoc.
 IPR000342; Regulat_G_prot_signal.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR013937; Sorting_nexin_C. 
Pfam
 PF08628; Nexin_C
 PF02194; PXA
 PF00615; RGS 
SMART
  
PROSITE
 PS51207; PXA 
PRINTS