UniProt Accession

 TF3C6_HUMAN; Q969F1; Q5VXN2 

Genbank Protein ID

 EF137904; AF361492; AF361496; AK057977; AL357515; CH471051; BC011593 

Genbank Nucleotide ID

 ABO33431.1; AAL57217.1; AAL57221.1; BAB71624.1; CAH73393.1; EAW48305.1; AAH11593.1 

Protein Name

 General transcription factor 3C polypeptide 6 

Protein Synonyms/Alias

 Transcription factor IIIC 35 kDa subunit; TFIIIC 35 kDa subunit; TFIIIC35; Transcription factor IIIC subunit 6 

Gene Name

 GTF3C6 

Gene Synonyms/Alias

 C6orf51; CDA020; NPD020 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
114	RTLLTEKKEGEENIG	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 9 9 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0000127; C:transcription factor TFIIIC complex; IDA:HGNC.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0042791; P:5S class rRNA transcription from RNA polymerase III type 1 promoter; IC:HGNC.
 GO:0042797; P:tRNA transcription from RNA polymerase III promoter; IC:HGNC. 

Interpro

 IPR019481; TFIIIC_tau55-rel. 

Pfam

 PF10419; TFIIIC_sub6 

SMART

  

PROSITE

  

PRINTS