UniProt Accession

 PPAC_HUMAN; P24666; A8K1L9; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0 

Genbank Protein ID

 M83653; M83654; U25849; U25847; U25848; S62884; S62885; M87545; AK289934; AK291861; BT007136; AC079779; CH471053; CH471053; BC007422; BC106011; L06508 

Genbank Nucleotide ID

 AAB59354.1; AAB59355.1; AAC52067.1; AAC52067.1; AAC52067.1; AAB27085.1; AAB27086.1; BAF82623.1; BAF84550.1; AAP35800.1; AAY14958.1; EAX01112.1; EAX01116.1; AAH07422.1; AAI06012.1; AAB59628.1 

Protein Name

 Low molecular weight phosphotyrosine protein phosphatase 

Protein Synonyms/Alias

 LMW-PTP; LMW-PTPase; Adipocyte acid phosphatase; Low molecular weight cytosolic acid phosphatase; Red cell acid phosphatase 1 

Gene Name

 ACP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MAEQATKSVLFVCL	ubiquitination	[1]
29	IAEAVFRKLVTDQNI	ubiquitination	[2]
113	QVKTCKAKIELLGSY	ubiquitination	[2, 3, 4, 5]
156	CCRAFLEKAH*****	acetylation	[6]
156	CCRAFLEKAH*****	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. 

Sequence Annotation

 ACT_SITE 13 13 Nucleophile (By similarity).
 ACT_SITE 19 19 By similarity.
 ACT_SITE 130 130 Proton donor (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 132 132 Phosphotyrosine.
 MOD_RES 133 133 Phosphotyrosine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 158 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0009898; C:internal side of plasma membrane; IDA:UniProtKB.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003993; F:acid phosphatase activity; TAS:ProtInc.
 GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0007268; P:synaptic transmission; IEA:Compara. 

Interpro

 IPR023485; Ptyr_pPase_SF.
 IPR002115; Tyr_Pase_low_mol_wt_mml.
 IPR000106; Tyr_phospatase/Ars_reductase.
 IPR017867; Tyr_phospatase_low_mol_wt. 

Pfam

 PF01451; LMWPc 

SMART

 SM00226; LMWPc 

PROSITE

  

PRINTS

 PR00719; LMWPTPASE.
 PR00720; MAMMALPTPASE.